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    Ntan1 N-terminal asparagine amidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ntan1provided by RGD
    Official Full Name
    N-terminal asparagine amidaseprovided by RGD
    Primary source
    RGD:1305160
    See related
    EnsemblRapid:ENSRNOG00000080737 AllianceGenome:RGD:1305160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305160
    Summary
    Predicted to enable protein-N-terminal asparagine amidohydrolase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within adult locomotory behavior and memory. Predicted to be located in cytoplasm and nucleus. Orthologous to human NTAN1 (N-terminal asparagine amidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 360.6), Kidney (RPKM 336.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ntan1 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2618239..2633185, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (2111090..2126119, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (3218414..3235229)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene bMERB domain containing 1 Neighboring gene nuclear receptor coactivator 4, pseudogene 1 Neighboring gene MPV17 mitochondrial inner membrane protein like Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene uncharacterized LOC102552514 Neighboring gene RRN3 homolog, RNA polymerase I transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase. Cantor JR, et al. Biochemistry, 2011 Apr 12. PMID 21375249, Free PMC Article
    2. Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 2000 Jun. PMID 10805755, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108792

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-N-terminal asparagine amidohydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein N-terminal asparagine amidohydrolase
    Names
    N-terminal Asn amidase
    NP_001020295.1
    NP_001380620.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025124.2 → NP_001020295.1  protein N-terminal asparagine amidohydrolase isoform 1

      See identical proteins and their annotated locations for NP_001020295.1

      Status: VALIDATED

      Source sequence(s)
      BC091175
      UniProtKB/TrEMBL
      A6K4F6, Q5BK79
      Related
      ENSRNOP00000098729.1, ENSRNOT00000127416.1
      Conserved Domains (1) summary
      pfam14736
      Location:39 → 304
      N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

    2. NM_001393691.1 → NP_001380620.1  protein N-terminal asparagine amidohydrolase isoform 2

      Status: VALIDATED

      Source sequence(s)
      FM043276, FM062658, JAXUCZ010000010
      UniProtKB/TrEMBL
      A6K4F7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      2618239..2633185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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