Slc25a12 solute carrier family 25 member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a12provided by RGD
Official Full Name: solute carrier family 25 member 12provided by RGD
Primary source: RGD:1305181
See related: EnsemblRapid:ENSRNOG00000022922 AllianceGenome:RGD:1305181
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Aralar1; RGD1561141
Summary: Predicted to enable amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Involved in several processes, including malate-aspartate shuttle; positive regulation of ATP biosynthetic process; and regulation of glucose metabolic process. Predicted to be located in mitochondrial inner membrane. Biomarker of fetal alcohol spectrum disorder. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 839.0), Heart (RPKM 421.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (76504868..76599536, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (56097166..56191841, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (57881951..57998214, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that down-regulation of the key component of the malate-aspartate shuttle AGC1/Aralar1 reduced glucose-induced oxidative metabolism and insulin secretion in INS-1E cells.
Title: Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.
Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development.
Title: Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.
Aralar1 has a role in determining glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells
Title: The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells.
aralar has an essential role in the transduction of small Ca2+ signals to neuronal mitochondria
Title: Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria.

Submit: New GeneRIF Correction

General gene information

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Markers

M2SSR54B (e-PCR)
- UniSTS:528954

RH139242 (e-PCR)
- UniSTS:221328

RH138988 (e-PCR)
- UniSTS:221074

RH135310 (e-PCR)
- UniSTS:218587

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-sulfino-L-alanine: proton, glutamate antiporter activity	IEA Inferred from Electronic Annotation more info
enables 3-sulfino-L-alanine: proton, glutamate antiporter activity	ISO Inferred from Sequence Orthology more info
enables 3-sulfino-L-alanine: proton, glutamate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-aspartate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables acidic amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables acidic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables aspartate:glutamate, proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables aspartate:glutamate, proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables aspartate:glutamate, proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in aspartate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in glutamate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate-aspartate shuttle	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate-aspartate shuttle	IEA Inferred from Electronic Annotation more info
involved_in malate-aspartate shuttle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within malate-aspartate shuttle	ISO Inferred from Sequence Orthology more info
involved_in malate-aspartate shuttle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucose catabolic process to lactate via pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutral amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

Names: calcium-binding mitochondrial carrier protein Aralar1; solute carrier family 25 (aspartate/glutamate carrier), member 12; solute carrier family 25 (mitochondrial carrier, Aralar), member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399269.2 → NP_001386198.1 electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

F1LX07

Related

ENSRNOP00000032909.8, ENSRNOT00000036728.8

Conserved Domains (3) summary

cl28896
Location:91 → 160

EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins

pfam00153
Location:514 → 609

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:15 → 80

EF-hand_7; EF-hand domain pair