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    Pja1 praja ring finger ubiquitin ligase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pja1provided by RGD
    Official Full Name
    praja ring finger ubiquitin ligase 1provided by RGD
    Primary source
    RGD:1591532
    See related
    EnsemblRapid:ENSRNOG00000047339 AllianceGenome:RGD:1591532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within protein catabolic process. Predicted to be located in cytoplasm. Orthologous to human PJA1 (praja ring finger ubiquitin ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 603.5), Kidney (RPKM 318.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pja1 in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (68621101..68626001, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (64580938..64585846, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (69213645..69218601, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene microRNA 3573 Neighboring gene ephrin B1 Neighboring gene ribosomal protein L27 like 1 Neighboring gene uncharacterized LOC120099284 Neighboring gene proliferating cell nuclear antigen, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation. Watabe K, et al. Neuropathology, 2020 Dec. PMID 32686212, Free PMC Article
    2. A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. Sasaki A, et al. J Biol Chem, 2002 Jun 21. PMID 11959851
    3. Praja1, a novel gene encoding a RING-H2 motif in mouse development. Mishra L, et al. Oncogene, 1997 Nov 6. PMID 9393880
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
      Title: Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Praja-1
    Names
    praja ring finger 1, E3 ubiquitin protein ligase
    NP_001094476.1
    NP_001385652.1
    NP_001385653.1
    XP_006257169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101006.2 → NP_001094476.1  E3 ubiquitin-protein ligase Praja-1 isoform 1

      See identical proteins and their annotated locations for NP_001094476.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      M0RCT9, Q66HF7
      Related
      ENSRNOP00000067423.2, ENSRNOT00000074071.4
      Conserved Domains (2) summary
      pfam13639
      Location:358 → 399
      zf-RING_2; Ring finger domain
      cl17018
      Location:325 → 358
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2

    2. NM_001398723.1 → NP_001385652.1  E3 ubiquitin-protein ligase Praja-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IQ68
      Conserved Domains (1) summary
      cd16465
      Location:537 → 582
      RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

    3. NM_001398724.1 → NP_001385653.1  E3 ubiquitin-protein ligase Praja-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6AEG5
      Related
      ENSRNOP00000111059.1, ENSRNOT00000144187.1
      Conserved Domains (1) summary
      cd16465
      Location:574 → 619
      RING-H2_PJA1_2; RING finger, H2 subclass, found in protein E3 ubiquitin-protein ligase Praja-1, Praja-2, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      68621101..68626001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257107.5 → XP_006257169.1  E3 ubiquitin-protein ligase Praja-1 isoform X1

      UniProtKB/TrEMBL
      M0RCT9
      Conserved Domains (2) summary
      pfam13639
      Location:395 → 436
      zf-RING_2; Ring finger domain
      cl17018
      Location:362 → 395
      FANC; Fanconi anemia ID complex proteins FANCI and FANCD2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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