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    Gstt3 glutathione S-transferase, theta 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499422, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Gstt3provided by RGD
    Official Full Name
    glutathione S-transferase, theta 3provided by RGD
    Primary source
    RGD:1562732
    See related
    EnsemblRapid:ENSRNOG00000001242 AllianceGenome:RGD:1562732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562732
    Expression
    Biased expression in Kidney (RPKM 991.7), Adrenal (RPKM 614.9) and 5 other tissues See more
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    Genomic context

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    See Gstt3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12873618..12881974)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12875184..12882540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13817795..13825475)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 4 Neighboring gene glutathione S-transferase theta 1 Neighboring gene uncharacterized LOC134483890 Neighboring gene D-dopachrome tautomerase Neighboring gene calcineurin binding protein 1 Neighboring gene uncharacterized LOC102556116

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression levels of pituitary tumor transforming 1 and glutathione-S-transferase theta 3 are associated with the individual susceptibility to D-galactosamine-induced hepatotoxicity. Yun JW, et al. Toxicol Appl Pharmacol, 2010 Jan 1. PMID 19800905
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gstt3 could predict inter-individual susceptibility to D-galactosamine induced hepatotoxicity
      Title: Expression levels of pituitary tumor transforming 1 and glutathione-S-transferase theta 3 are associated with the individual susceptibility to D-galactosamine-induced hepatotoxicity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase, theta 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399042.1 → NP_001385971.1  glutathione S-transferase, theta 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I5ZLR0
      Related
      ENSRNOP00000094988.2, ENSRNOT00000114782.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12873618..12881974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279467.1 → XP_063135537.1  glutathione S-transferase, theta 3 isoform X2

    2. XM_063279466.1 → XP_063135536.1  glutathione S-transferase, theta 3 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001137643.1: Suppressed sequence

      Description
      NM_001137643.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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