Lamtor3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamtor3provided by RGD
Official Full Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3provided by RGD
Primary source: RGD:1307133
See related: EnsemblRapid:ENSRNOG00000088035 AllianceGenome:RGD:1307133
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MP1; Mapksp1; Map2k1ip1
Summary: Predicted to enable kinase activator activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and protein localization. Predicted to act upstream of or within positive regulation of MAPK cascade and protein localization to cell junction. Predicted to be located in late endosome membrane. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in late endosome and lysosomal membrane. Orthologous to human LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 185.1), Muscle (RPKM 138.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (229084795..229097028)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (226411389..226423612)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (243160821..243173057)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The MP1/p14 complex regulates PAK1-dependent ERK activation during adhesion and cell spreading but is not required for ERK activation by platelet-derived growth factor.
Title: The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
contributes_to guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activator activity	IEA Inferred from Electronic Annotation more info
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
contributes_to molecular adaptor activity	ISO Inferred from Sequence Orthology more info
contributes_to molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to cell junction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to cell junction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FNIP-folliculin RagC/D GAP	IEA Inferred from Electronic Annotation more info
part_of FNIP-folliculin RagC/D GAP	ISO Inferred from Sequence Orthology more info
part_of Ragulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ragulator complex	IEA Inferred from Electronic Annotation more info
part_of Ragulator complex	ISO Inferred from Sequence Orthology more info
part_of Ragulator complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ragulator complex protein LAMTOR3

Names: MEK partner 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen-activated protein kinase kinase 1-interacting protein 1; mitogen-activated protein kinase scaffold protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008375.1 → NP_001008376.1 ragulator complex protein LAMTOR3

See identical proteins and their annotated locations for NP_001008376.1

Status: PROVISIONAL

Source sequence(s)

BC086353

UniProtKB/Swiss-Prot

Q5U204

UniProtKB/TrEMBL

A0A8L2Q6U4, A6HW13

Related

ENSRNOP00000105487.1, ENSRNOT00000128241.1

Conserved Domains (1) summary

pfam08923
Location:3 → 121

MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting
NM_001429142.1 → NP_001416071.1 ragulator complex protein LAMTOR3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q5U204

UniProtKB/TrEMBL

A0A8L2Q6U4, A6HW13
NM_001429143.1 → NP_001416072.1 ragulator complex protein LAMTOR3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q5U204

UniProtKB/TrEMBL

A0A8L2Q6U4, A6HW13

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

229084795..229097028

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282225.1 → XP_063138295.1 ragulator complex protein LAMTOR3 isoform X1
XM_006233383.5 → XP_006233445.1 ragulator complex protein LAMTOR3 isoform X2

Conserved Domains (1) summary

pfam08923
Location:3 → 121

MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting
XM_006233385.5 → XP_006233447.1 ragulator complex protein LAMTOR3 isoform X2

Conserved Domains (1) summary

pfam08923
Location:3 → 121

MAPKK1_Int; Mitogen-activated protein kinase kinase 1 interacting
XM_063282224.1 → XP_063138294.1 ragulator complex protein LAMTOR3 isoform X1
XM_063282222.1 → XP_063138292.1 ragulator complex protein LAMTOR3 isoform X1