Trak2 trafficking kinesin protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trak2provided by RGD
Official Full Name: trafficking kinesin protein 2provided by RGD
Primary source: RGD:620915
See related: EnsemblRapid:ENSRNOG00000010881 AllianceGenome:RGD:620915
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GRIF-1; Als2cr3
Summary: Enables several functions, including GABA receptor binding activity; TPR domain binding activity; and kinesin binding activity. Involved in several processes, including dendrite morphogenesis; dendritic transport of mitochondrion; and negative regulation of axonogenesis. Located in several cellular components, including axonal growth cone; early endosome; and neuronal cell body. Orthologous to human TRAK2 (trafficking kinesin protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 565.1), Spleen (RPKM 396.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q31

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (67842680..67909786, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (60348531..60414036, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (65698706..65763351, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons.
Title: GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.
GRIF1 may participate in microtubule-based transport of early endosomes by acting as an adaptor linking Hrs-containing endosomes to kinesin.
Title: GRIF1 binds Hrs and is a new regulator of endosomal trafficking.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d9rat118 (e-PCR)
- UniSTS:122495

RH127778 (e-PCR)
- UniSTS:211088

RH140019 (e-PCR)
- UniSTS:222101

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GABA receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables GABA receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables TPR domain binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinesin binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic transport of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion distribution	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter transport	NAS Non-traceable Author Statement more info	PubMed
involved_in protein O-linked glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trafficking kinesin-binding protein 2

Names: GABA-A receptor interacting factor-1; O-GlcNAc transferase-interacting protein of 98 kDa; amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog; trafficking protein, kinesin binding 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133560.2 → NP_598244.2 trafficking kinesin-binding protein 2

See identical proteins and their annotated locations for NP_598244.2

Status: VALIDATED

Source sequence(s)

AJ288898, BC088393

UniProtKB/Swiss-Prot

Q8R2H6, Q8R2H7, Q8R4G3

UniProtKB/TrEMBL

A6IP85, A6IP87

Conserved Domains (2) summary

pfam04849
Location:50 → 353

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:426 → 565

Milton; Kinesin associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

67842680..67909786 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266622.1 → XP_063122692.1 trafficking kinesin-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q8R2H6, Q8R2H7, Q8R4G3

UniProtKB/TrEMBL

A6IP85, A6IP87
XM_063266621.1 → XP_063122691.1 trafficking kinesin-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q8R2H6, Q8R2H7, Q8R4G3

UniProtKB/TrEMBL

A6IP85, A6IP87
XM_063266623.1 → XP_063122693.1 trafficking kinesin-binding protein 2 isoform X4

UniProtKB/TrEMBL

A6IP86
XM_063266620.1 → XP_063122690.1 trafficking kinesin-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q8R2H6, Q8R2H7, Q8R4G3

UniProtKB/TrEMBL

A6IP85, A6IP87
XM_017596256.3 → XP_017451745.1 trafficking kinesin-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A0G2K434, A6IP85

Conserved Domains (2) summary

pfam04849
Location:50 → 372

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:445 → 584

Milton; Kinesin associated protein
XM_008767072.3 → XP_008765294.1 trafficking kinesin-binding protein 2 isoform X1

See identical proteins and their annotated locations for XP_008765294.1

UniProtKB/TrEMBL

A0A0G2K434, A6IP85

Related

ENSRNOP00000015035.5, ENSRNOT00000015034.9

Conserved Domains (2) summary

pfam04849
Location:50 → 372

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:445 → 584

Milton; Kinesin associated protein
XM_039082996.2 → XP_038938924.1 trafficking kinesin-binding protein 2 isoform X3

Conserved Domains (2) summary

pfam04849
Location:50 → 372

HAP1_N; HAP1 N-terminal conserved region

pfam12448
Location:433 → 584

Milton; Kinesin associated protein