Hp haptoglobin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hpprovided by RGD
Official Full Name: haptoglobinprovided by RGD
Primary source: RGD:2825
See related: EnsemblRapid:ENSRNOG00000014964 AllianceGenome:RGD:2825
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ba1-647
Summary: Enables hemoglobin binding activity and identical protein binding activity. Involved in several processes, including response to L-ascorbic acid; response to cobalamin; and response to growth hormone. Located in blood microparticle. Used to study obesity and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); kidney failure (multiple); liver disease (multiple); and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Plasmodium falciparum malaria; artery disease (multiple); gout; hemolytic anemia; and hyperglycemia. Orthologous to human HP (haptoglobin) and HPR (haptoglobin-related protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 45420.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (54449151..54453701, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (37539626..37544178, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (42096255..42100805)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonistrated that increased Hp in serum came from the liver in response to TBI and that IL-6 is an important mediator of this induction.
Title: Elevated serum haptoglobin after traumatic brain injury is synthesized mainly in liver.
Vaccenic acid normalizes serum haptoglobin in obese/insulin resistant JCR:LA-cp rats
Title: Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR: LA-cp rats.
activated glucocorticoid receptor through direct interactions with STAT3 and C/EBPbeta, participates in Hp gene upregulation as a transcriptional coactivator.
Title: Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response.
Pulmonary embolism that causes pulmonary hypertension is associated with haptoglobin depletion and up-regulation of HMOX1 enzyme.
Title: Rapid clearance of circulating haptoglobin from plasma during acute pulmonary embolism in rats results in HMOX1 up-regulation in peripheral blood leukocytes.
Haptoglobin deficiency worsens intracerebral hemorrhage whereas haptoglobin overexpression alleviates intracerebral hemorrhage-mediated brain injury.
Title: Neuroprotective role of haptoglobin after intracerebral hemorrhage.
lamin components of the nuclear matrix form a network of functional, dynamic protein-protein and protein-Hp-S/MAR associations with multiple partners, and underline the involvement of PARP-1 in the regulation of haptoglobin gene transcription.
Title: Regulation of rat haptoglobin gene expression is coordinated by the nuclear matrix.
Data concluded that haptoglobin gene up-regulation during chronic dietary restriction was regulated by different mechanisms than during the acute phase response.
Title: Differences between molecular mechanisms involved in the regulation of haptoglobin gene expression during the acute phase response and dietary restriction.
Western blotting and enzyme-linked immunosorbent assay clearly showed a markedly increased level of Hp in the urine, but not in the serum, of the PHN animals.
Title: Markedly increased urinary preprohaptoglobin and haptoglobin in passive Heymann nephritis: a differential proteomics approach.
that interactions between C/EBPs and HDAC1 negatively regulate C/EBPdelta-dependent haptoglobin expression in intestinal epithelial cells.
Title: Regulation of C/EBPdelta-dependent transactivation by histone deacetylases in intestinal epithelial cells.
upregulated in reactive astrocytes after transient forebrain ischemia in rats
Title: Upregulation of haptoglobin in reactive astrocytes after transient forebrain ischemia in rats.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

d19mgh5 (e-PCR)
- UniSTS:121359

D19Arb2 (e-PCR), detects polymorphism
- UniSTS:226962

D19Wox9 (e-PCR)
- UniSTS:240609

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables hemoglobin binding	IDA Inferred from Direct Assay more info	PubMed
enables hemoglobin binding	IEA Inferred from Electronic Annotation more info
enables hemoglobin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in liver development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to cobalamin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dimethyl sulfoxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in blood microparticle	IBA Inferred from Biological aspect of Ancestor more info
located_in blood microparticle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of haptoglobin-hemoglobin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: haptoglobin

Names: liver regeneration-related protein LRRG173; zonulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012582.2 → NP_036714.2 haptoglobin precursor

See identical proteins and their annotated locations for NP_036714.2

Status: PROVISIONAL

Source sequence(s)

BC089816

UniProtKB/Swiss-Prot

P06866, Q5EBB4, Q7TP23

UniProtKB/TrEMBL

A0A0H2UHM3, A6IZ24

Related

ENSRNOP00000085960.1, ENSRNOT00000118054.2

Conserved Domains (3) summary

cd00033
Location:33 → 87

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00020
Location:102 → 340

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:103 → 343

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...