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    Ptger2 prostaglandin E receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81752, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ptger2provided by RGD
    Official Full Name
    prostaglandin E receptor 2provided by RGD
    Primary source
    RGD:620020
    See related
    EnsemblRapid:ENSRNOG00000050968 AllianceGenome:RGD:620020
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    EP2; Ptger-ep2
    Summary
    Enables prostaglandin E receptor activity. Involved in positive regulation of gastric mucosal blood circulation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance. Orthologous to human PTGER2 (prostaglandin E receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 19.1), Lung (RPKM 12.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ptger2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (20694765..20708475)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18215013..18228714)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19336029..19349759)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene Smad nuclear interacting protein 1, pseudogene 2 Neighboring gene uncharacterized LOC134482089 Neighboring gene uncharacterized LOC120096941 Neighboring gene uncharacterized LOC120096942 Neighboring gene ribosomal protein S10 like 6 Neighboring gene thioredoxin domain containing 16 Neighboring gene G protein-coupled receptor 137C Neighboring gene REST corepressor 2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin E receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables prostaglandin E receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to prostaglandin E stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to prostaglandin E stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of gastric mucosal blood circulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to nematode ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to progesterone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP2 subtype
    Names
    PGE receptor, EP2 subtype
    PGE2 receptor EP2 subtype
    prostaglandin E receptor 2 (subtype EP2)
    prostaglandin E receptor EP2 subtype
    prostaglandin E2 receptor EP2 subtype-like
    prostaglandin E2 receptor type 2
    prostanoid EP2 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031088.2NP_112350.1  prostaglandin E2 receptor EP2 subtype

      See identical proteins and their annotated locations for NP_112350.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q547S0, Q62928
      UniProtKB/TrEMBL
      A6KDY9
      Related
      ENSRNOP00000064907.1, ENSRNOT00000075209.4
      Conserved Domains (1) summary
      pfam00001
      Location:39314
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      20694765..20708475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093687.2XP_038949615.1  prostaglandin E2 receptor EP2 subtype isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:2450
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:24281
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_001841264.3 RNA Sequence