Dhrs9 dehydrogenase/reductase 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhrs9provided by RGD
Official Full Name: dehydrogenase/reductase 9provided by RGD
Primary source: RGD:620655
See related: EnsemblRapid:ENSRNOG00000065735 AllianceGenome:RGD:620655
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rdhl
Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in retinoic acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human DHRS9 (dehydrogenase/reductase 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 93.2), Thymus (RPKM 54.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (74553357..74579535)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (54147834..54170052)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (55623671..55645883)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This novel short-chain alcohol dehydrogenase is an excellent candidate for the retinol dehydrogenase that catalyzes the first step in retinoic acid biosynthesis that occurs in uterine epithelial cells
Title: A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 9-cis-retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 9-cis-retinoic acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 9

Names: 3-alpha hydroxysteroid dehydrogenase; 3-alpha-HSD; 3alpha-HSD; dehydrogenase/reductase (SDR family) member 9; retinol dehydrogenase homolog; short-chain dehydrogenase/reductase retSDR8

NP_570832.1

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.53

XP_063139097.1

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130819.3 → NP_570832.1 dehydrogenase/reductase SDR family member 9 precursor

See identical proteins and their annotated locations for NP_570832.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8VD48

Related

ENSRNOP00000091619.1, ENSRNOT00000106393.2

Conserved Domains (1) summary

cd09805
Location:30 → 306

type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs