Cuzd1 CUB and zona pellucida-like domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cuzd1provided by RGD
Official Full Name: CUB and zona pellucida-like domains 1provided by RGD
Primary source: RGD:619771
See related: EnsemblRapid:ENSRNOG00000029945 AllianceGenome:RGD:619771
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Uo; ERG1; UO-44; Utczp; Itmap1
Summary: Involved in hormone-mediated signaling pathway. Predicted to be located in zymogen granule membrane. Predicted to be active in cell surface and extracellular space. Orthologous to human CUZD1 (CUB and zona pellucida like domains 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 746.6), Spleen (RPKM 166.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (195519609..195532733, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (186089422..186130536, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (201881846..201894970, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The arrhythmogenic effect of a crude extract from sea anemone Condylactis gigantea possibly involves rErg1 channels.
Title: Arrhythmogenic effect of a crude extract from sea anemone Condylactis gigantea: possible involvement of rErg1 channels.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133442 (e-PCR)
- UniSTS:216725

RH130932 (e-PCR)
- UniSTS:214216

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in female pregnancy	NAS Non-traceable Author Statement more info	PubMed
involved_in female pregnancy	TAS Traceable Author Statement more info	PubMed
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in trypsinogen activation	IEA Inferred from Electronic Annotation more info
involved_in trypsinogen activation	ISO Inferred from Sequence Orthology more info
involved_in trypsinogen activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in zymogen granule	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CUB and zona pellucida-like domain-containing protein 1

Names: CUB and ZP domain-containing protein 1; estrogen-regulated gene 1; estrogen-regulated protein 1; integral membrane-associated protein 1; uterine-ovarian-specific gene 44; uterus/ovary-specific protein 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054005.2 → NP_446457.2 CUB and zona pellucida-like domain-containing protein 1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6HWV5, F1M8L3

Related

ENSRNOP00000045430.4, ENSRNOT00000050519.7

Conserved Domains (3) summary

smart00042
Location:55 → 143

CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein

smart00241
Location:277 → 519

ZP; Zona pellucida (ZP) domain

pfam00431
Location:154 → 262

CUB; CUB domain