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    Blvra biliverdin reductase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Blvraprovided by RGD
    Official Full Name
    biliverdin reductase Aprovided by RGD
    Primary source
    RGD:620721
    See related
    EnsemblRapid:ENSRNOG00000011778 AllianceGenome:RGD:620721
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables biliberdin reductase (NAD+) activity. Predicted to be involved in heme catabolic process. Predicted to be active in cytosol. Orthologous to human BLVRA (biliverdin reductase A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 414.9), Spleen (RPKM 296.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Blvra in Genome Data Viewer
    Location:
    3q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134793397..134819367)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (114340778..114366048)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (119552550..119577796)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene signal peptide peptidase-like 2A Neighboring gene uncharacterized LOC134486145 Neighboring gene mitochondrial fission regulator 1-like Neighboring gene adaptor related protein complex 4 subunit epsilon 1 Neighboring gene uncharacterized LOC134486146 Neighboring gene non-SMC condensin I complex, subunit H Neighboring gene ITPRIP like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway. Song S, et al. Exp Cell Res, 2013 Aug 1. PMID 23722043
    2. Crystallization and preliminary X-ray diffraction analysis of a rat biliverdin reductase. Sun D, et al. Acta Crystallogr D Biol Crystallogr, 2000 Sep. PMID 10957639
    3. Site-directed mutagenesis of cysteine residues in biliverdin reductase. Roles in substrate and cofactor binding. McCoubrey WK Jr, et al. Eur J Biochem, 1994 Jun 1. PMID 8020496
    4. Expression and characterization of a cDNA for rat kidney biliverdin reductase. Evidence suggesting the liver and kidney enzymes are the same transcript product. Fakhrai H, et al. J Biol Chem, 1992 Feb 25. PMID 1371282
    5. Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. Whitby FG, et al. J Mol Biol, 2002 Jun 21. PMID 12079357

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BVR contributes to the inhibitory process of hypoxia on pulmonary arterial smooth muscle cell apoptosis, which is mediated by bilirubin through ERK1/2 pathway.
      Title: Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway.
    2. Data show that siRNA blockage of BVR protein expression in cardiomyocytes inhibits HO-2 protein induction but not vice versa.
      Title: The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunction.
    3. X-ray crystal structures of apo rat BVR and its complex with NADH at 1.2 A and 1.5 A resolution, respectively
      Title: Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex.
    4. Results describe the activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.
      Title: Activation of biliverdin-IXalpha reductase by inorganic phosphate and related anions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables biliberdin reductase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables biliberdin reductase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables biliverdin reductase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biliverdin reductase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biliverdin reductase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables biliverdin reductase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biliverdin reductase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables biliverdin reductase [NAD(P)+] activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    biliverdin reductase A
    Names
    BVR A
    biliverdin-IX alpha-reductase
    NP_446302.2
    XP_006234956.1
    XP_006234957.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429702.1 → NP_001416631.1  biliverdin reductase A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P46844
      UniProtKB/TrEMBL
      F7EW70, Q6AZ33

    2. NM_053850.3 → NP_446302.2  biliverdin reductase A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P46844
      UniProtKB/TrEMBL
      F7EW70, Q6AZ33
      Conserved Domains (2) summary
      pfam01408
      Location:18 → 124
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:132 → 242
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      134793397..134819367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234894.5 → XP_006234956.1  biliverdin reductase A isoform X1

      Related
      ENSRNOP00000015843.3, ENSRNOT00000015843.8
      Conserved Domains (2) summary
      pfam01408
      Location:18 → 124
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:132 → 242
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    2. XM_006234895.5 → XP_006234957.1  biliverdin reductase A isoform X1

      Conserved Domains (2) summary
      pfam01408
      Location:18 → 124
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:132 → 242
      Biliv-reduc_cat; Biliverdin reductase, catalytic
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46844.1 GenPept UniProtKB/Swiss-Prot:P46844

    Gene LinkOut

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