Lcat lecithin cholesterol acyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lcatprovided by RGD
Official Full Name: lecithin cholesterol acyltransferaseprovided by RGD
Primary source: RGD:2993
See related: EnsemblRapid:ENSRNOG00000019573 AllianceGenome:RGD:2993
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphatidylcholine-sterol O-acyltransferase activity and phospholipase A2 activity. Involved in several processes, including aflatoxin metabolic process; cholesterol metabolic process; and response to copper ion. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Used to study end stage renal disease; familial hyperlipidemia; and myocardial infarction. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1462.7) and Brain (RPKM 58.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50744598..50748064, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (33834748..33838214, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (37913333..37916799, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134132 (e-PCR)
- UniSTS:217414

Lcat (e-PCR), detects polymorphism
- UniSTS:507015

RH129859 (e-PCR)
- UniSTS:213147

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IEA Inferred from Electronic Annotation more info
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISO Inferred from Sequence Orthology more info
enables apolipoprotein A-I binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-sterol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine-sterol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylcholine-sterol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine-sterol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables platelet-activating factor acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables platelet-activating factor acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sterol ester esterase activity	IEA Inferred from Electronic Annotation more info
enables sterol ester esterase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aflatoxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipoprotein biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of high-density lipoprotein particle assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in response to copper ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylcholine-sterol acyltransferase

Names: 1-alkyl-2-acetylglycerophosphocholine esterase; Lecithin-cholesterol acyltransferase; PAF acetylhydrolase; phospholipid-cholesterol acyltransferase; platelet-activating factor acetylhydrolase

NP_058720.2

EC 2.3.1.43

EC 3.1.1.47

XP_006255503.1

EC 2.3.1.43

EC 3.1.1.47

XP_038953400.1

EC 2.3.1.43

EC 3.1.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017024.3 → NP_058720.2 phosphatidylcholine-sterol acyltransferase precursor

See identical proteins and their annotated locations for NP_058720.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

O35849, P18424

UniProtKB/TrEMBL

A0A8L2QED8, A6IYU6

Related

ENSRNOP00000026583.5, ENSRNOT00000026585.7

Conserved Domains (1) summary

cl21494
Location:83 → 408

Abhydrolase; alpha/beta hydrolases

RNA

NR_190829.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50744598..50748064 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097472.2 → XP_038953400.1 phosphatidylcholine-sterol acyltransferase isoform X1

Conserved Domains (1) summary

cl21494
Location:59 → 384

Abhydrolase; alpha/beta hydrolases
XM_006255441.3 → XP_006255503.1 phosphatidylcholine-sterol acyltransferase isoform X2

Related

ENSRNOP00000100686.1, ENSRNOT00000163120.1

Conserved Domains (2) summary

COG0596
Location:125 → 301

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

cl21494
Location:44 → 369

Abhydrolase; alpha/beta hydrolases