Maml2 mastermind-like transcriptional coactivator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maml2provided by RGD
Official Full Name: mastermind-like transcriptional coactivator 2provided by RGD
Primary source: RGD:1587536
See related: EnsemblRapid:ENSRNOG00000005879 AllianceGenome:RGD:1587536
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription of Notch receptor target. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human MAML2 (mastermind like transcriptional coactivator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 80.4), Spleen (RPKM 63.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (18552480..18869923)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (10268611..10588307)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (11929238..12253991)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

RH134840 (e-PCR)
- UniSTS:218118

BE121402 (e-PCR)
- UniSTS:248090

stSG625620 (e-PCR)
- UniSTS:456791

D11Rat118 (e-PCR), detects polymorphism
- UniSTS:226411

BF398711 (e-PCR)
- UniSTS:246896

BE097189 (e-PCR)
- UniSTS:244610

RH118320 (e-PCR)
- UniSTS:124331

RH143399 (e-PCR)
- UniSTS:232646

BE116653 (e-PCR)
- UniSTS:248522

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription of Notch receptor target	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mastermind-like protein 2

Names: mastermind like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

18552480..18869923

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765997.4 → XP_008764219.2 mastermind-like protein 2 isoform X1

UniProtKB/TrEMBL

F1M3B2

Related

ENSRNOP00000037050.7, ENSRNOT00000036338.8

Conserved Domains (1) summary

pfam09596
Location:31 → 88

MamL-1; MamL-1 domain
XM_039082226.2 → XP_038938154.1 mastermind-like protein 2 isoform X2