IFNE interferon epsilon [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFNEprovided by HGNC
Official Full Name: interferon epsilonprovided by HGNC
Primary source: HGNC:HGNC:18163
See related: Ensembl:ENSG00000184995 MIM:615223; AllianceGenome:HGNC:18163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IFN-E; IFNE1; IFNT1; INFE1; PRO655
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; lymphocyte activation involved in immune response; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: mouse all
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Genomic context

Location:: 9p21.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (21480839..21482313, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (21495017..21496491, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (21480838..21482312, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of IFNE in cervical biopsies of patients with high-risk human papillomavirus infections.
Title: Upregulation of IFNE in cervical biopsies of patients with high-risk human papillomavirus infections.
Interferon-epsilon is a tumour suppressor and restricts ovarian cancer.
Title: Interferon-ε is a tumour suppressor and restricts ovarian cancer.
Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection.
Title: Constitutive expression and distinct properties of IFN-epsilon protect the female reproductive tract from Zika virus infection.
Spatiotemporal regulation of human IFN-epsilon and innate immunity in the female reproductive tract.
Title: Spatiotemporal regulation of human IFN-ε and innate immunity in the female reproductive tract.
average vaginal IFNe across pregnancy was lower in women with genital herpes simplex virus compared to healthy women
Title: Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study.
IFN epsilon protects macrophages against HIV infection through a type I IFN independent mechanism.
Title: IFN-ε protects primary macrophages against HIV infection.
human IFNvarepsilon suppresses HIV replication at multiple stages of infection.
Title: Interferon epsilon promotes HIV restriction at multiple steps of viral replication.
female sex workers decreased susceptibility to HIV-1 infection also have increased levels of IFNE gene and protein expression in the cervical epithelium
Title: HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes.
T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-epsilon is a risk factor for the development of intracerebral hemorrhage.
Title: T Allele of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-ε is a risk factor for the development of intracerebral hemorrhage.
Full-length IFN-epsilon 5'UTR markedly suppressed mRNA expression under basal conditions. It contains 2 stable stem-loop structures which associate with importin 9. Loop 1 is essential for regulation of mRNA expression.
Title: Novel role for molecular transporter importin 9 in posttranscriptional regulation of IFN-ε expression.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
THOC5: a novel gene involved in HDL-cholesterol metabolism. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484186

IFNT1_2211 (e-PCR)
- UniSTS:280775

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables type I interferon receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in B cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to virus	NAS Non-traceable Author Statement more info	PubMed
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to exogenous dsRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interferon epsilon

Names: IFN-epsilon; interferon epsilon 1; interferon tau-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.