Slc5a8 solute carrier family 5 member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a8provided by RGD
Official Full Name: solute carrier family 5 member 8provided by RGD
Primary source: RGD:1564146
See related: EnsemblRapid:ENSRNOG00000006367 AllianceGenome:RGD:1564146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564146
Summary: Predicted to enable lactate transmembrane transporter activity; monocarboxylate:sodium symporter activity; and propionate transmembrane transporter activity. Predicted to be involved in several processes, including monoatomic anion transport; monocarboxylic acid transport; and nitrate transmembrane transport. Predicted to act upstream of or within lactate transmembrane transport and short-chain fatty acid transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be part of GINS complex. Orthologous to human SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 211.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (25160280..25201185)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (23272891..23313811)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (29434175..29476807)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A high affinity type of SMCT1-like transporter, additionally in operation in the ileum, is involved in the transport of nicotinate.
Title: Nicotinate uptake by two kinetically distinct Na÷-dependent carrier-mediated transport systems in the rat small intestine.
Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha on butyrate absorption could have potential therapeutic value.
Title: The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function.
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.
Title: Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lactate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monocarboxylate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables organic acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables propionate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables short-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetate transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
involved_in lactate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monocarboxylic acid transport	ISO Inferred from Sequence Orthology more info
involved_in nicotinate transport	ISO Inferred from Sequence Orthology more info
involved_in nitrate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in propanoate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within propanoate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in propanoate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within short-chain fatty acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GINS complex	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-coupled monocarboxylate transporter 1

Names: solute carrier family 5 (iodide transporter), member 8; solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191987.1 → NP_001178916.1 sodium-coupled monocarboxylate transporter 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6A218, D3Z9E5

Related

ENSRNOP00000008613.7, ENSRNOT00000008613.9

Conserved Domains (1) summary

cd11519
Location:7 → 549

SLC5sbd_SMCT1; Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain