Fn3k fructosamine 3 kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fn3kprovided by RGD
Official Full Name: fructosamine 3 kinaseprovided by RGD
Primary source: RGD:1559983
See related: EnsemblRapid:ENSRNOG00000036659 AllianceGenome:RGD:1559983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fnsk
Summary: Predicted to enable protein-fructosamine 3-kinase activity. Predicted to be involved in epithelial cell differentiation and protein deglycation. Predicted to act upstream of or within fructosamine metabolic process. Orthologous to human FN3K (fructosamine 3 kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 102.9), Brain (RPKM 97.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (107198566..107214176)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (106700670..106715903)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (110626462..110642262)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fructosamine 3-kinase and fructosamine 3-kinase-related protein have roles in repairing damage caused by ribose 5-phosphate [FN3K, FN3K-RP]
Title: Tissue distribution and evolution of fructosamine 3-kinase and fructosamine 3-kinase-related protein.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-fructosamine 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-ribulosamine 3-kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fructosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fructosamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine deglycation	ISO Inferred from Sequence Orthology more info
involved_in protein deglycation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fructosamine-3-kinase

NP_001102521.2

EC 2.7.1.171

EC 2.7.1.172

XP_038942579.1

EC 2.7.1.171

EC 2.7.1.172

XP_038942580.1

EC 2.7.1.171

EC 2.7.1.172

XP_063125743.1

EC 2.7.1.171

EC 2.7.1.172

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109051.2 → NP_001102521.2 fructosamine-3-kinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D3ZZU8

Related

ENSRNOP00000051798.4, ENSRNOT00000054915.6

Conserved Domains (1) summary

cl21453
Location:21 → 309

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

107198566..107214176

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086651.2 → XP_038942579.1 fructosamine-3-kinase isoform X2

UniProtKB/TrEMBL

A0A8I6AW19

Related

ENSRNOP00000089005.2, ENSRNOT00000103390.2

Conserved Domains (1) summary

cl21453
Location:3 → 165

PKc_like; Protein Kinases, catalytic domain
XM_039086652.2 → XP_038942580.1 fructosamine-3-kinase isoform X3

Conserved Domains (1) summary

cl21453
Location:3 → 163

PKc_like; Protein Kinases, catalytic domain
XM_063269673.1 → XP_063125743.1 fructosamine-3-kinase isoform X1