Acot8 acyl-CoA thioesterase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acot8provided by RGD
Official Full Name: acyl-CoA thioesterase 8provided by RGD
Primary source: RGD:70368
See related: EnsemblRapid:ENSRNOG00000015187 AllianceGenome:RGD:70368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pte1
Summary: Enables choloyl-CoA hydrolase activity and fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process. Located in peroxisome. Orthologous to human ACOT8 (acyl-CoA thioesterase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 118.5), Liver (RPKM 65.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173950530..173962188, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (153531192..153542851, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (161260837..161272495, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetoacetyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables choloyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydroxymethylglutaryl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
NOT enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables medium-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables succinyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in acyl-CoA metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dicarboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in dicarboxylic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CD4 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of CD4 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in peroxisome fission	IEA Inferred from Electronic Annotation more info
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IEA Inferred from Electronic Annotation more info
located_in peroxisomal matrix	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 8

Names: 4,8-dimethylnonanoyl-CoA thioesterase; 48-dimethylnonanoyl-CoA thioesterase; PTE-1; PTE-2; choloyl-coenzyme A thioesterase; peroxisomal acyl-CoA thioesterase 1; peroxisomal acyl-CoA thioesterase 2; peroxisomal acyl-coenzyme A thioester hydrolase 1; peroxisomal long-chain acyl-CoA thioesterase 1

NP_570112.3

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

XP_038960095.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

XP_038960096.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

XP_038960097.1

EC 3.1.2.1

EC 3.1.2.11

EC 3.1.2.2

EC 3.1.2.27

EC 3.1.2.3

EC 3.1.2.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130756.3 → NP_570112.3 acyl-coenzyme A thioesterase 8

Status: VALIDATED

Source sequence(s)

BC078751, CV115391

UniProtKB/TrEMBL

F7F557, Q6AZ44

Related

ENSRNOP00000020740.4, ENSRNOT00000020740.8

Conserved Domains (3) summary

cd03444
Location:260 → 363

Thioesterase_II_repeat1; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...

cd03445
Location:94 → 185

Thioesterase_II_repeat2; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...

TIGR00189
Location:89 → 364

tesB; acyl-CoA thioesterase II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

173950530..173962188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104167.2 → XP_038960095.1 acyl-coenzyme A thioesterase 8 isoform X1

Conserved Domains (1) summary

TIGR00189
Location:92 → 243

tesB; acyl-CoA thioesterase II
XM_039104168.2 → XP_038960096.1 acyl-coenzyme A thioesterase 8 isoform X2

UniProtKB/TrEMBL

A6JXB6

Conserved Domains (1) summary

TIGR00189
Location:3 → 227

tesB; acyl-CoA thioesterase II
XM_039104169.2 → XP_038960097.1 acyl-coenzyme A thioesterase 8 isoform X3

Conserved Domains (1) summary

TIGR00189
Location:5 → 226

tesB; acyl-CoA thioesterase II