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    Arhgef25 Rho guanine nucleotide exchange factor 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgef25provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 25provided by RGD
    Primary source
    RGD:735210
    See related
    EnsemblRapid:ENSRNOG00000005034 AllianceGenome:RGD:735210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Geft
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance. Predicted to be located in myofibril. Predicted to be active in cytoplasm and plasma membrane. Predicted to be extrinsic component of membrane. Orthologous to human ARHGEF25 (Rho guanine nucleotide exchange factor 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 89.2), Brain (RPKM 80.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef25 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64891260..64898382, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63005938..63013325, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70469304..70476633, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 like 1 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1 Neighboring gene solute carrier family 26, member 10 Neighboring gene uncharacterized LOC134479708 Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RhoA promotes differentiation of WB-F344 cells into the biliary lineage. Yao H, et al. Differentiation, 2009 Feb. PMID 19281775
    2. Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain. Qu MJ, et al. Ann Biomed Eng, 2008 Sep. PMID 18566890
    3. p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts. Ongherth A, et al. J Mol Cell Cardiol, 2015 Nov. PMID 26392029
    4. Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity. Smith TK, et al. Proc Natl Acad Sci U S A, 2008 Jun 17. PMID 18541910, Free PMC Article
    5. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. Guo X, et al. J Biol Chem, 2003 Apr 11. PMID 12547822

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF.
      Title: p63RhoGEF regulates auto- and paracrine signaling in cardiac fibroblasts.
    2. cells with ectopically active RhoA expression were found to form bile-duct-like structures even without Matrigel treatment
      Title: RhoA promotes differentiation of WB-F344 cells into the biliary lineage.
    3. the frequency-dependent expression of h1-calponin under cyclic strain is mediated at least partly by the regulation of Rac and Rho-GDI alpha expression on the activation of p38 pathway
      Title: Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72605

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myofibril ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 25
    Names
    RAC/CDC42 exchange factor
    Rho guanine nucleotide exchange factor (GEF) 25
    RhoA/RAC/CDC42 exchange factor
    guanine nucleotide exchange factor GEFT
    rac/Cdc42/Rho exchange factor GEFT
    rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400956.1 → NP_001387885.1  rho guanine nucleotide exchange factor 25

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AFR6, A0A8L2Q2D0, A6HQT2
      Related
      ENSRNOP00000006800.6, ENSRNOT00000006800.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64891260..64898382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241455.5 → XP_006241517.1  rho guanine nucleotide exchange factor 25 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3X0, A0A8I6AFR6
      Conserved Domains (2) summary
      cd13241
      Location:346 → 488
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:171 → 342
      RhoGEF; RhoGEF domain

    2. XM_006241458.5 → XP_006241520.1  rho guanine nucleotide exchange factor 25 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AFR6
      Conserved Domains (2) summary
      cd13241
      Location:369 → 511
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:194 → 365
      RhoGEF; RhoGEF domain

    3. XM_039079147.2 → XP_038935075.1  rho guanine nucleotide exchange factor 25 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A2C8
      Conserved Domains (2) summary
      cd13241
      Location:296 → 438
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:121 → 291
      RhoGEF; RhoGEF domain

    4. XM_063263506.1 → XP_063119576.1  rho guanine nucleotide exchange factor 25 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AL50
      Related
      ENSRNOP00000087274.2, ENSRNOT00000107552.2

    5. XM_006241456.5 → XP_006241518.1  rho guanine nucleotide exchange factor 25 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AL50
      Related
      ENSRNOP00000086978.2, ENSRNOT00000100160.2
      Conserved Domains (2) summary
      cd13241
      Location:339 → 481
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:164 → 335
      RhoGEF; RhoGEF domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199395.1: Suppressed sequence

      Description
      NM_199395.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P720.1 GenPept UniProtKB/Swiss-Prot:Q6P720

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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