Vtcn1 V-set domain containing T cell activation inhibitor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vtcn1provided by RGD
Official Full Name: V-set domain containing T cell activation inhibitor 1provided by RGD
Primary source: RGD:1311204
See related: EnsemblRapid:ENSRNOG00000015279 AllianceGenome:RGD:1311204
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311204
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; negative regulation of T cell proliferation; and negative regulation of apoptotic process. Predicted to act upstream of or within positive regulation of interleukin-2 production; regulation of T cell activation; and response to protozoan. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human VTCN1 (V-set domain containing T cell activation inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 29.2), Uterus (RPKM 25.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (190942224..191010280)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (188253594..188321658)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (203200435..203274264)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI556616 (e-PCR)
- UniSTS:244680

BM386831 (e-PCR)
- UniSTS:261591

Vtcn1 (e-PCR), detects polymorphism
- UniSTS:478943

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to protozoan	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: V-set domain-containing T-cell activation inhibitor 1

Names: immune costimulatory protein B7-H4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024244.1 → NP_001019415.1 V-set domain-containing T-cell activation inhibitor 1 precursor

See identical proteins and their annotated locations for NP_001019415.1

Status: PROVISIONAL

Source sequence(s)

BC095842

UniProtKB/Swiss-Prot

Q501W4

UniProtKB/TrEMBL

A0A8I6AL42, A6K3G7

Related

ENSRNOP00000020566.4, ENSRNOT00000020566.8

Conserved Domains (2) summary

smart00410
Location:46 → 144

IG_like; Immunoglobulin like

cl11960
Location:49 → 146

Ig; Immunoglobulin domain