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    Mok MOK protein kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362787, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mokprovided by RGD
    Official Full Name
    MOK protein kinaseprovided by RGD
    Primary source
    RGD:1309274
    See related
    EnsemblRapid:ENSRNOG00000007850 AllianceGenome:RGD:1309274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rage
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in ciliary base. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOK (MOK protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 77.4), Brain (RPKM 33.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mok in Genome Data Viewer
    Location:
    6q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (135645018..135675894, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (129823794..129854669, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (135228755..135259645, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35A like 2 Neighboring gene WD repeat domain 20 Neighboring gene uncharacterized LOC108351302 Neighboring gene transfer RNA isoleucine (anticodon AAU) 3 Neighboring gene zinc finger protein 839 Neighboring gene cyclin-dependent kinase 2-interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Receptor for advanced glycation end products (RAGE) mediates neuronal differentiation and neurite outgrowth. Wang L, et al. J Neurosci Res, 2008 May 1. PMID 18058943
    2. Modulation of RAGE expression influences the adhesion of red blood cells from diabetic patients. Wautier MP, et al. Clin Hemorheol Microcirc, 2006. PMID 16899960
    3. Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma. Oehlrich N, et al. Int J Cancer, 2005 Nov 1. PMID 15900605
    4. Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells. Uesaka T, et al. FEBS Lett, 2004 Aug 27. PMID 15327990
    5. Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells. Broekhuis JR, et al. PLoS One, 2014. PMID 25243405, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2 [MOK]
      Title: Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94988

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MAPK/MAK/MRK overlapping kinase
    Names
    renal tumor antigen
    NP_001382039.1
    XP_008763166.2
    XP_038968491.1
    XP_038968493.1
    XP_038968494.1
    XP_038968496.1
    XP_038968500.1
    XP_038968502.1
    XP_038968504.1
    XP_038968507.1
    XP_038968510.1
    XP_063118206.1
    XP_063118207.1
    XP_063118208.1
    XP_063118209.1
    XP_063118210.1
    XP_063118211.1
    XP_063118212.1
    XP_063118213.1
    XP_063118214.1
    XP_063118215.1
    XP_063118216.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395110.1 → NP_001382039.1  MAPK/MAK/MRK overlapping kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6KBN2, F7F4B1
      Related
      ENSRNOP00000010529.6, ENSRNOT00000010529.7
      Conserved Domains (1) summary
      cd07831
      Location:4 → 285
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    RNA

    1. NR_172487.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      135645018..135675894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262138.1 → XP_063118208.1  MAPK/MAK/MRK overlapping kinase isoform X3

      UniProtKB/TrEMBL
      A0A0G2JWI7
      Related
      ENSRNOP00000069896.3, ENSRNOT00000088986.3

    2. XM_039112566.2 → XP_038968494.1  MAPK/MAK/MRK overlapping kinase isoform X10

      Conserved Domains (1) summary
      cl21453
      Location:1 → 193
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063262145.1 → XP_063118215.1  MAPK/MAK/MRK overlapping kinase isoform X16

    4. XM_063262141.1 → XP_063118211.1  MAPK/MAK/MRK overlapping kinase isoform X6

    5. XM_063262140.1 → XP_063118210.1  MAPK/MAK/MRK overlapping kinase isoform X5

    6. XM_063262136.1 → XP_063118206.1  MAPK/MAK/MRK overlapping kinase isoform X1

    7. XM_063262137.1 → XP_063118207.1  MAPK/MAK/MRK overlapping kinase isoform X2

    8. XM_039112582.2 → XP_038968510.1  MAPK/MAK/MRK overlapping kinase isoform X14

      Conserved Domains (1) summary
      cl21453
      Location:1 → 103
      PKc_like; Protein Kinases, catalytic domain

    9. XM_008764944.4 → XP_008763166.2  MAPK/MAK/MRK overlapping kinase isoform X7

    10. XM_063262139.1 → XP_063118209.1  MAPK/MAK/MRK overlapping kinase isoform X4

    11. XM_039112572.2 → XP_038968500.1  MAPK/MAK/MRK overlapping kinase isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    12. XM_039112574.2 → XP_038968502.1  MAPK/MAK/MRK overlapping kinase isoform X14

      Conserved Domains (1) summary
      cl21453
      Location:1 → 103
      PKc_like; Protein Kinases, catalytic domain

    13. XM_039112565.2 → XP_038968493.1  MAPK/MAK/MRK overlapping kinase isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:6 → 195
      PKc_like; Protein Kinases, catalytic domain

    14. XM_039112568.1 → XP_038968496.1  MAPK/MAK/MRK overlapping kinase isoform X11

      Conserved Domains (1) summary
      cl21453
      Location:1 → 180
      PKc_like; Protein Kinases, catalytic domain

    15. XM_039112563.1 → XP_038968491.1  MAPK/MAK/MRK overlapping kinase isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:6 → 195
      PKc_like; Protein Kinases, catalytic domain

    16. XM_063262142.1 → XP_063118212.1  MAPK/MAK/MRK overlapping kinase isoform X8

    17. XM_039112576.2 → XP_038968504.1  MAPK/MAK/MRK overlapping kinase isoform X14

      Conserved Domains (1) summary
      cl21453
      Location:1 → 103
      PKc_like; Protein Kinases, catalytic domain

    18. XM_039112579.2 → XP_038968507.1  MAPK/MAK/MRK overlapping kinase isoform X15

      Conserved Domains (1) summary
      cl21453
      Location:13 → 101
      PKc_like; Protein Kinases, catalytic domain

    19. XM_063262143.1 → XP_063118213.1  MAPK/MAK/MRK overlapping kinase isoform X12

    20. XM_063262146.1 → XP_063118216.1  MAPK/MAK/MRK overlapping kinase isoform X17

    21. XM_063262144.1 → XP_063118214.1  MAPK/MAK/MRK overlapping kinase isoform X13

    RNA

    1. XR_010052122.1 RNA Sequence

    2. XR_010052123.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001010965.1: Suppressed sequence

      Description
      NM_001010965.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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