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    Gpr132 G protein-coupled receptor 132 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr132provided by RGD
    Official Full Name
    G protein-coupled receptor 132provided by RGD
    Primary source
    RGD:1310817
    See related
    EnsemblRapid:ENSRNOG00000013914 AllianceGenome:RGD:1310817
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G2a
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G1/S transition of mitotic cell cycle and negative regulation of G2/M transition of mitotic cell cycle. Predicted to be located in membrane. Orthologous to human GPR132 (G protein-coupled receptor 132). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 81.1), Spleen (RPKM 54.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr132 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137745142..137763037, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131924061..131943327, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137652213..137671658, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene cell division cycle associated 4 Neighboring gene keratin-associated protein 5-9-like Neighboring gene jagged canonical Notch ligand 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Weng Z, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770487, Free PMC Article
    2. Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor. Ikeno Y, et al. J Biol Chem, 2005 Jul 29. PMID 15927955
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2a (G protein-coupled receptor 132).
      Title: Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 132
    Names
    G protein-coupled receptor G2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170595.1 → NP_001164066.1  probable G-protein coupled receptor 132

      See identical proteins and their annotated locations for NP_001164066.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AM45, A6KBW8, D3ZIH1
      Related
      ENSRNOP00000018613.3, ENSRNOT00000018613.5
      Conserved Domains (2) summary
      cd14964
      Location:72 → 97
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:48 → 315
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137745142..137763037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594191.3 → XP_017449680.1  probable G-protein coupled receptor 132 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AM45, A6KBW8, D3ZIH1
      Conserved Domains (2) summary
      cd14964
      Location:72 → 97
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:48 → 315
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006240661.5 → XP_006240723.1  probable G-protein coupled receptor 132 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A964, A0A8I6AM45
      Related
      ENSRNOP00000095175.1, ENSRNOT00000110419.2
      Conserved Domains (1) summary
      pfam00001
      Location:146 → 395
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. XM_039112425.2 → XP_038968353.1  probable G-protein coupled receptor 132 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AM45, A6KBW8, D3ZIH1
      Conserved Domains (2) summary
      cd14964
      Location:72 → 97
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:48 → 315
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_039112426.2 → XP_038968354.1  probable G-protein coupled receptor 132 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM45
      Conserved Domains (2) summary
      cd14964
      Location:24 → 49
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:2 → 267
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_039112427.1 → XP_038968355.1  probable G-protein coupled receptor 132 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM45
      Conserved Domains (2) summary
      cd14964
      Location:24 → 49
      7tm_GPCRs; TM helix 2 [structural motif]
      cl28897
      Location:2 → 267
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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