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    Memo1 mediator of cell motility 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298787, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Memo1provided by RGD
    Official Full Name
    mediator of cell motility 1provided by RGD
    Primary source
    RGD:1309929
    See related
    EnsemblRapid:ENSRNOG00000006340 AllianceGenome:RGD:1309929
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309929
    Summary
    Predicted to be involved in regulation of microtubule-based process. Orthologous to human MEMO1 (mediator of cell motility 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 347.4), Spleen (RPKM 330.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Memo1 in Genome Data Viewer
    Location:
    6q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (26895497..26986248)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (21144525..21234363)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (22362483..22409583)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18A, pseudogene 5 Neighboring gene uncharacterized LOC120103480 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene high mobility group box 2, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Zaoui K, et al. Proc Natl Acad Sci U S A, 2010 Oct 26. PMID 20937854, Free PMC Article
    2. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116222

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule-based process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein MEMO1
    Names
    mediator of ErbB2-driven cell motility 1
    memo-1
    protein memo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029917.1 → NP_001025088.1  protein MEMO1

      See identical proteins and their annotated locations for NP_001025088.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098061
      UniProtKB/Swiss-Prot
      Q4QQR9
      UniProtKB/TrEMBL
      F1LNE5
      Related
      ENSRNOP00000080510.1, ENSRNOT00000107877.2
      Conserved Domains (1) summary
      cd07361
      Location:9 → 294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      26895497..26986248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261616.1 → XP_063117686.1  protein MEMO1 isoform X3

    2. XM_063261615.1 → XP_063117685.1  protein MEMO1 isoform X2

    3. XM_063261614.1 → XP_063117684.1  protein MEMO1 isoform X1

    4. XM_039111900.1 → XP_038967828.1  protein MEMO1 isoform X4

      UniProtKB/Swiss-Prot
      Q4QQR9
      UniProtKB/TrEMBL
      F1LNE5
      Related
      ENSRNOP00000008687.4, ENSRNOT00000008687.7
      Conserved Domains (1) summary
      cd07361
      Location:9 → 294
      MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

    5. XM_039111903.2 → XP_038967831.1  protein MEMO1 isoform X5

      Conserved Domains (1) summary
      cl00599
      Location:114 → 198
      Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

    RNA

    1. XR_010052056.1 RNA Sequence

      Related
      ENSRNOT00000133440.1

    2. XR_010052055.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQR9.1 GenPept UniProtKB/Swiss-Prot:Q4QQR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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