Kif26a kinesin family member 26A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif26aprovided by RGD
Official Full Name: kinesin family member 26Aprovided by RGD
Primary source: RGD:1307957
See related: EnsemblRapid:ENSRNOG00000013661 AllianceGenome:RGD:1307957
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including nervous system development; regulation of cell growth by extracellular stimulus; and regulation of neuron migration. Predicted to be located in cytoplasm and cytoskeleton. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 63.1), Heart (RPKM 52.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (137035986..137072027)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (131214839..131250874)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (136720254..136755515)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
NOT enables microtubule motor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in enteric nervous system development	ISO Inferred from Sequence Orthology more info
NOT involved_in microtubule-based movement	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth by extracellular stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF26A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170348.2 → NP_001163819.1 kinesin-like protein KIF26A isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

D3ZUT0

Conserved Domains (3) summary

smart00129
Location:365 → 725

KISc; Kinesin motor, catalytic domain. ATPase

PRK07764
Location:837 → 1309

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00106
Location:364 → 716

KISc; Kinesin motor domain
NM_001414931.1 → NP_001401860.1 kinesin-like protein KIF26A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

Related

ENSRNOP00000018278.6, ENSRNOT00000018278.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

137035986..137072027

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240635.5 → XP_006240697.1 kinesin-like protein KIF26A isoform X1

UniProtKB/TrEMBL

A0A0G2JWJ1

Related

ENSRNOP00000069901.2, ENSRNOT00000086868.3

Conserved Domains (3) summary

smart00129
Location:365 → 725

KISc; Kinesin motor, catalytic domain. ATPase

PRK07764
Location:837 → 1309

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd00106
Location:364 → 716

KISc; Kinesin motor domain
XM_039112423.2 → XP_038968351.1 kinesin-like protein KIF26A isoform X2

Conserved Domains (3) summary

PHA03247
Location:868 → 1394

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:1185 → 1455

PHA03307; transcriptional regulator ICP4; Provisional

cd00106
Location:102 → 454

KISc; Kinesin motor domain