U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lrrc43 leucine rich repeat containing 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288751, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lrrc43provided by RGD
    Official Full Name
    leucine rich repeat containing 43provided by RGD
    Primary source
    RGD:1561461
    See related
    EnsemblRapid:ENSRNOG00000008470 AllianceGenome:RGD:1561461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dynein complex binding activity. Predicted to be involved in axoneme assembly. Predicted to be active in axoneme. Orthologous to human LRRC43 (leucine rich repeat containing 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 24.4), Lung (RPKM 5.5) and 1 other tissue See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lrrc43 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38735033..38753143, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33074149..33092257, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38507102..38524715, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene VPS33A core subunit of CORVET and HOPS complexes Neighboring gene diablo, IAP-binding mitochondrial protein Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Neighboring gene interleukin 31 Neighboring gene MLX interacting protein Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    leucine-rich repeat-containing protein 43

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170396.2 → NP_001163867.1  leucine-rich repeat-containing protein 43

      Status: VALIDATED

      Source sequence(s)
      BC083905, JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6ANQ5, Q5XHZ4
      Related
      ENSRNOP00000094870.1, ENSRNOT00000104058.2
      Conserved Domains (4) summary
      cd00116
      Location:146 → 254
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:147 → 168
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:146 → 187
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:146 → 203
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38735033..38753143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools