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    Cntn1 contactin 1 [ Mus musculus (house mouse) ]

    Gene ID: 12805, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cntn1provided by MGI
    Official Full Name
    contactin 1provided by MGI
    Primary source
    MGI:MGI:105980
    See related
    Ensembl:ENSMUSG00000055022 AllianceGenome:MGI:105980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    usl; CNTN; F3cam
    Summary
    Enables carbohydrate binding activity. Involved in central nervous system myelin formation and locomotory behavior. Acts upstream of or within several processes, including nervous system development; positive regulation of neuron projection development; and positive regulation of sodium ion transport. Located in myelin sheath. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Used to study Compton-North congenital myopathy. Human ortholog(s) of this gene implicated in Compton-North congenital myopathy. Orthologous to human CNTN1 (contactin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 20.9), cortex adult (RPKM 17.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cntn1 in Genome Data Viewer
    Location:
    15 E3; 15 46.39 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (91949034..92239834)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (92051152..92341967)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 2 pseudogene Neighboring gene leucine-rich repeat LGI family, member 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:91964733-91964842 Neighboring gene STARR-seq mESC enhancer starr_39509 Neighboring gene predicted gene, 36901 Neighboring gene STARR-positive B cell enhancer mm9_chr15:92171487-92171788 Neighboring gene STARR-seq mESC enhancer starr_39511 Neighboring gene predicted gene, 26760 Neighboring gene predicted gene, 53194 Neighboring gene PDZ domain containing RING finger 4 Neighboring gene STARR-seq mESC enhancer starr_39512 Neighboring gene predicted gene, 52207

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neurons. Bizzoca A, et al. Development, 2003 Jan. PMID 12441289
    2. A spontaneous mutation in contactin 1 in the mouse. Davisson MT, et al. PLoS One, 2011. PMID 22242131, Free PMC Article
    3. Significance of F3/Contactin gene expression in cerebral cortex and nigrostriatal development. Massaro A, et al. Mol Cell Neurosci, 2012 Jul. PMID 22579730
    4. The mouse F3/contactin glycoprotein: structural features, functional properties and developmental significance of its regulated expression. Bizzoca A, et al. Cell Adh Migr, 2009 Jan-Mar. PMID 19372728, Free PMC Article
    5. Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. Mikami T, et al. J Biol Chem, 2009 Feb 13. PMID 19075012

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
      Title: CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.
    2. Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma.
      Title: Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma.
    3. ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
      Title: ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.
    4. Contactin-1 secreted by oligodendrocytes is a novel factor that influences nodal protein clustering in hippocampus.
      Title: Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS.
    5. Study confirmed that the HNK-1 epitope was primarily expressed on TNC in the embryonic day 16 mouse brain and promoted neurite outgrowth. That this signal was mediated by CNTN, which is an HNK-1-expressing neuronal receptor. These results suggest that the HNK-1 epitope is a key modifier of TNC and CNTN in the regulation of embryonic brain development.
      Title: Site-specific HNK-1 epitope on alternatively spliced fibronectin type-III repeats in tenascin-C promotes neurite outgrowth of hippocampal neurons through contactin-1.
    6. Data indicate that Contactin-1 expression is dependent upon EBF factors; Cntn1 gene belongs to the expanding regulatory cascade driven by these transcriptional regulators so that changes in its activation may contribute to the Ebf2 null mutant phenotype
      Title: The gene encoding the mouse contactin-1 axonal glycoprotein is regulated by the collier/Olf1/EBF family early B-Cell factor 2 transcription factor.
    7. It plays a role in hippocampal synaptic plasticity and memory also in aged mice, suggesting that it acts on molecular pathways related to apoptosis and amyloid-beta production.
      Title: Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice.
    8. The F3/contactin plays a role in promoting adult hippocampal neurogenesis and that this effect correlates with improved synaptic function and memory.
      Title: F3/Contactin promotes hippocampal neurogenesis, synaptic plasticity, and memory in adult mice.
    9. Contactin-1 has roles in regulating myelination and nodal/paranodal domain organization in the central nervous system
      Title: Contactin-1 regulates myelination and nodal/paranodal domain organization in the central nervous system.
    10. In developing cerebral cortex and basal ganglia the F3/Contactin gene is mostly activated during early commitment of neuronal precursors.
      Title: Significance of F3/Contactin gene expression in cerebral cortex and nigrostriatal development.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system myelin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myelination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    contactin-1
    Names
    neural cell surface protein F3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159647.2 → NP_001153119.1  contactin-1 precursor

      See identical proteins and their annotated locations for NP_001153119.1

      Status: VALIDATED

      Source sequence(s)
      AC100736, AC125460
      Consensus CDS
      CCDS27763.1
      UniProtKB/Swiss-Prot
      P12960, Q6NXV7, Q8BR42, Q8C6A0
      Related
      ENSMUSP00000067842.6, ENSMUST00000068378.6
      Conserved Domains (9) summary
      cd05851
      Location:241 → 328
      IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
      cd00063
      Location:612 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:813 → 895
      fn3; Fibronectin type III domain
      cd00096
      Location:332 → 335
      Ig; Ig strand A [structural motif]
      cd04970
      Location:503 → 603
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:142 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd05849
      Location:40 → 134
      IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
      cd05852
      Location:413 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    2. NM_001159648.2 → NP_001153120.1  contactin-1 precursor

      See identical proteins and their annotated locations for NP_001153120.1

      Status: VALIDATED

      Source sequence(s)
      AC100736, AC125460, AC162863
      Consensus CDS
      CCDS27763.1
      UniProtKB/Swiss-Prot
      P12960, Q6NXV7, Q8BR42, Q8C6A0
      Related
      ENSMUSP00000133063.2, ENSMUST00000169825.8
      Conserved Domains (9) summary
      cd05851
      Location:241 → 328
      IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
      cd00063
      Location:612 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:813 → 895
      fn3; Fibronectin type III domain
      cd00096
      Location:332 → 335
      Ig; Ig strand A [structural motif]
      cd04970
      Location:503 → 603
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:142 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd05849
      Location:40 → 134
      IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
      cd05852
      Location:413 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    3. NM_001358051.2 → NP_001344980.1  contactin-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC100736, AC125460, AC162863
      Consensus CDS
      CCDS27763.1
      UniProtKB/Swiss-Prot
      P12960, Q6NXV7, Q8BR42, Q8C6A0
      Conserved Domains (9) summary
      cd05851
      Location:241 → 328
      IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
      cd00063
      Location:612 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:813 → 895
      fn3; Fibronectin type III domain
      cd00096
      Location:332 → 335
      Ig; Ig strand A [structural motif]
      cd04970
      Location:503 → 603
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:142 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd05849
      Location:40 → 134
      IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
      cd05852
      Location:413 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    4. NM_001411171.1 → NP_001398100.1  contactin-1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC100736, AC125460, AC162863
      UniProtKB/Swiss-Prot
      P12960, Q6NXV7, Q8BR42, Q8C6A0

    5. NM_007727.3 → NP_031753.1  contactin-1 precursor

      See identical proteins and their annotated locations for NP_031753.1

      Status: VALIDATED

      Source sequence(s)
      AC100736, AC125460, AC162863
      Consensus CDS
      CCDS27763.1
      UniProtKB/Swiss-Prot
      P12960, Q6NXV7, Q8BR42, Q8C6A0
      Related
      ENSMUSP00000000109.5, ENSMUST00000000109.11
      Conserved Domains (9) summary
      cd05851
      Location:241 → 328
      IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
      cd00063
      Location:612 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:813 → 895
      fn3; Fibronectin type III domain
      cd00096
      Location:332 → 335
      Ig; Ig strand A [structural motif]
      cd04970
      Location:503 → 603
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:142 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd05849
      Location:40 → 134
      IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
      cd05852
      Location:413 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      91949034..92239834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520383.5 → XP_006520446.1  contactin-1 isoform X2

      Conserved Domains (6) summary
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cd04970
      Location:520 → 604
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    2. XM_036159111.1 → XP_036015004.1  contactin-1 isoform X1

      UniProtKB/Swiss-Prot
      P12960, Q6NXV7, Q8BR42, Q8C6A0
      Conserved Domains (9) summary
      cd05851
      Location:241 → 328
      IgI_3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily (IgSF) domains
      cd00063
      Location:612 → 699
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:813 → 895
      fn3; Fibronectin type III domain
      cd00096
      Location:332 → 335
      Ig; Ig strand A [structural motif]
      cd04970
      Location:503 → 603
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cd05727
      Location:142 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains
      cd05849
      Location:40 → 134
      IgI_1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1; member of the I-set of Ig superfamily domains
      cd05852
      Location:413 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain

    3. XM_017316423.3 → XP_017171912.1  contactin-1 isoform X2

      Conserved Domains (6) summary
      cd05727
      Location:134 → 230
      Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
      cd05849
      Location:40 → 132
      Ig1_Contactin-1; First immunoglobulin (Ig) domain of contactin-1
      cd05851
      Location:241 → 328
      Ig3_Contactin-1; Third immunoglobulin (Ig) domain of contactin-1
      cd05852
      Location:429 → 501
      Ig5_Contactin-1; Fifth immunoglobulin (Ig) domain of contactin-1
      cd04970
      Location:520 → 604
      Ig6_Contactin; Sixth immunoglobulin (Ig) domain of contactin
      cl11960
      Location:332 → 408
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12960.1 GenPept UniProtKB/Swiss-Prot:P12960

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