Or5d18 olfactory receptor family 5 subfamily D member 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or5d18provided by MGI
Official Full Name: olfactory receptor family 5 subfamily D member 18provided by MGI
Primary source: MGI:MGI:2151908
See related: Ensembl:ENSMUSG00000075140 AllianceGenome:MGI:2151908
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Olfr73; mOR-EG; MOR174-9; fascin-1
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: 2 D; 2 49.98 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (87864540..87865481, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (88034196..88035137, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The binding pocket of the prototypical olfactory receptor Olfr73 is smaller, but more flexible, than binding pockets of typical non-olfactory G-protein-coupled receptors. A molecular basis for reduced interaction contacts between an odorant and its OR and thus the typical low potency of OR-activating compounds.
Title: Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds.
The odorant-binding site lies in a hydrophobic pocket formed by TM3, TM5, and TM6. Phe252 in TM6 of mOR-EG appears to be critical in switching the receptor conformation from an inactive to an active state.
Title: Structural basis for a broad but selective ligand spectrum of a mouse olfactory receptor: mapping the odorant-binding site.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables odorant binding	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: olfactory receptor family 5 subfamily D member 18

Names: GA_x6K02T2Q125-49527073-49526132; olfactory receptor 73; olfactory receptor MOR174-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054090.1 → NP_473431.1 olfactory receptor family 5 subfamily D member 18

See identical proteins and their annotated locations for NP_473431.1

Status: PROVISIONAL

Source sequence(s)

AB061228

Consensus CDS

CCDS16322.1

UniProtKB/TrEMBL

Q920P2

Related

ENSMUSP00000097426.2, ENSMUST00000099838.2

Conserved Domains (2) summary

pfam00001
Location:42 → 291

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:32 → 309

7tm_4; Olfactory receptor