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    Zfp768 zinc finger protein 768 [ Mus musculus (house mouse) ]

    Gene ID: 233890, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp768provided by MGI
    Official Full Name
    zinc finger protein 768provided by MGI
    Primary source
    MGI:MGI:2384582
    See related
    Ensembl:ENSMUSG00000047371 AllianceGenome:MGI:2384582
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf768
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in chromosome and nucleus. Is expressed in several structures, including cerebellum external granule cell layer; genitourinary system; neural retina; olfactory epithelium; and skeletal muscle. Orthologous to human ZNF768 (zinc finger protein 768). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 31.6), adrenal adult (RPKM 24.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp768 in Genome Data Viewer
    Location:
    7 F3; 7 69.47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126941967..126944486, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127342795..127345314, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6606 Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134439631-134439814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134439816-134439925 Neighboring gene integrin alpha L Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134452009-134452210 Neighboring gene STARR-positive B cell enhancer ABC_E9709 Neighboring gene STARR-positive B cell enhancer ABC_E11368 Neighboring gene STARR-positive B cell enhancer ABC_E9710 Neighboring gene ferredoxin 1-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9711 Neighboring gene zinc finger protein 747

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC31345

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 768

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146202.1 → NP_666314.1  zinc finger protein 768

      See identical proteins and their annotated locations for NP_666314.1

      Status: PROVISIONAL

      Source sequence(s)
      BC026432
      Consensus CDS
      CCDS21864.1
      UniProtKB/Swiss-Prot
      Q8R0T2
      Related
      ENSMUSP00000055374.6, ENSMUST00000060783.7
      Conserved Domains (4) summary
      COG5048
      Location:327 → 532
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:487 → 507
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:541 → 563
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:359 → 382
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126941967..126944486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0T2.1 GenPept UniProtKB/Swiss-Prot:Q8R0T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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