Kcnb2 potassium voltage gated channel, Shab-related subfamily, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnb2provided by MGI
Official Full Name: potassium voltage gated channel, Shab-related subfamily, member 2provided by MGI
Primary source: MGI:MGI:99632
See related: Ensembl:ENSMUSG00000092083 AllianceGenome:MGI:99632
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kv2.2; 9630047L19Rik
Summary: Predicted to enable several functions, including delayed rectifier potassium channel activity; protein heterodimerization activity; and transmembrane transporter binding activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and protein localization to plasma membrane. Predicted to be located in neuronal cell body membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendrite; membrane; and neuronal cell body. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and sensory organ. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 2.3), cortex adult (RPKM 1.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A3; 1 4.5 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (15357149..15793975)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (15286925..15723751)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings demonstrate a conserved in vivo function for Kv2 family members in remodeling neuronal endoplasmic reticulum-plasma membrane junctions.
Title: Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.
The fractional contribution of Kv2.2-mediated currents relative to IK decreases during the postnatal maturation of dorsal root ganglion neurons.
Title: The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons.
The protein levels of KV4.3 and KV2.2 were up-regulated in the hypertrophic smooth muscle cell membrane.
Title: Voltage dependent potassium channel remodeling in murine intestinal smooth muscle hypertrophy induced by partial obstruction.
This study demonistrated that the contribution of Kv2.2 potassium channels in regulating neuronal excitability and a specific role in hearing protection after an acoustic insult. Kv2.2 is expressed in two nuclei of the superior olivary complex.
Title: Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system.
Kv2.2 modulates somatostatin release in delta-cells.
Title: The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
These data offer Kv2.2 as a molecular target to study the role of the specific subpopulation of basal forebrain GABAergic neurons.
Title: Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.
It was concluded that Kv2.2-containing channels have a distinctive initial segment location and crucial function in maintaining AP amplitude by regulating the interspike potential during high frequency firing.
Title: Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB431852 (e-PCR)
- UniSTS:207128

D2Mit330 (e-PCR), detects polymorphism
- UniSTS:129224

Kcnb2 (e-PCR), detects polymorphism
- UniSTS:531454

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily B member 2

Names: voltage-gated potassium channel subunit Kv2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098528.3 → NP_001091998.1 potassium voltage-gated channel subfamily B member 2

See identical proteins and their annotated locations for NP_001091998.1

Status: VALIDATED

Source sequence(s)

AC126049, AC166075

Consensus CDS

CCDS48222.1

UniProtKB/Swiss-Prot

A6H8H5, E9Q5T7

Related

ENSMUSP00000135382.2, ENSMUST00000175681.3

Conserved Domains (5) summary

smart00225
Location:37 → 143

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:230 → 428

Ion_trans; Ion transport protein

pfam02214
Location:37 → 136

BTB_2; BTB/POZ domain

pfam03521
Location:471 → 755

Kv2channel; Kv2 voltage-gated K+ channel

pfam07885
Location:341 → 422

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

15357149..15793975

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495597.5 → XP_006495660.1 potassium voltage-gated channel subfamily B member 2 isoform X1

See identical proteins and their annotated locations for XP_006495660.1

Conserved Domains (2) summary

pfam00520
Location:1 → 183

Ion_trans; Ion transport protein

pfam03521
Location:226 → 510

Kv2channel; Kv2 voltage-gated K+ channel
XM_006495596.3 → XP_006495659.1 potassium voltage-gated channel subfamily B member 2 isoform X1

See identical proteins and their annotated locations for XP_006495659.1

Conserved Domains (2) summary

pfam00520
Location:1 → 183

Ion_trans; Ion transport protein

pfam03521
Location:226 → 510

Kv2channel; Kv2 voltage-gated K+ channel