Homer2 homer scaffolding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Homer2provided by MGI
Official Full Name: homer scaffolding protein 2provided by MGI
Primary source: MGI:MGI:1347354
See related: Ensembl:ENSMUSG00000025813 AllianceGenome:MGI:1347354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CPD; Vesl-2; 9330120H11Rik
Summary: Enables actin binding activity and synaptic receptor adaptor activity. Involved in sensory perception of sound. Acts upstream of or within behavioral response to cocaine; calcium-mediated signaling; and regulation of G protein-coupled receptor signaling pathway. Located in apical part of cell; cytoplasm; and stereocilium tip. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; cranial nerve; jaw; sensory organ; and tongue. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 7.6), cortex adult (RPKM 4.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 45.71 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (81250229..81356673, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (81600481..81706925, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice.
Title: Reciprocal Homer1a and Homer2 Isoform Expression Is a Key Mechanism for Muscle Soleus Atrophy in Spaceflown Mice.
The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells.
Title: The physiological role of Homer2a and its novel short isoform, Homer2e, in NMDA receptor-mediated apoptosis in cerebellar granule cells.
Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.
Title: Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues.
Data indicate decreased bone density in homer scaffolding proteins (omer2/3) double knockout (DKO) mice.
Title: Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism.
The present results provide novel cause-effect evidence supporting a role for CEA Homer2 in the regulation of both basal anxiety and the time-dependent intensification of negative affective states in individuals with a history of binge-drinking during adolescence.
Title: Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking.
detected an additional 15 novel Homer2-interacting proteins, most of which are part of the N-methyl-D-aspartate receptor signaling pathway. These results corroborate the central role Homer2 plays in glutamatergic transmission and expand the network of proteins potentially contributing to the behavioral abnormalities associated with altered Homer2 expression
Title: A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain.
stress-alcohol locomotor cross-sensitization was regulated by Homer2.
Title: Homer2 regulates alcohol and stress cross-sensitization.
NMDA receptor function, but not ethanol sensitivity, is reduced in hippocampal neurons lacking the Homer2 gene
Title: Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
mouse mutants homozygous for the targeted deletion of Homer2 present with early-onset rapidly progressive hearing loss.
Title: HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice.
Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (PMCA) by Homer2 protein that has a central role on PMCA-mediated Ca(2+) signaling in parotid acinar cells.
Title: Homer2 protein regulates plasma membrane Ca²⁺-ATPase-mediated Ca²⁺ signaling in mouse parotid gland acinar cells.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW539445 (e-PCR)
- UniSTS:179598

AB017136 (e-PCR)
- UniSTS:179599

Homer2 (e-PCR), detects polymorphism
- UniSTS:531419

Homer2 (e-PCR), detects polymorphism
- UniSTS:531452

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled glutamate receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables synaptic receptor adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium tip	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homer protein homolog 2

Names: VASP/Ena-related gene up-regulated during seizure and LTP 2; cupidin; homer homolog 2; homer, neuronal immediate early gene, 2; homer-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164086.1 → NP_001157558.1 homer protein homolog 2 isoform 2

See identical proteins and their annotated locations for NP_001157558.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC140366, AF093259, AK163423

Consensus CDS

CCDS85329.1

UniProtKB/Swiss-Prot

Q9QWW1

Related

ENSMUSP00000026922.9, ENSMUST00000026922.15

Conserved Domains (2) summary

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02169
Location:100 → 315

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
NM_001164087.1 → NP_001157559.1 homer protein homolog 2 isoform 3

See identical proteins and their annotated locations for NP_001157559.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC140366, AF093260, CJ083069, DV657327

Consensus CDS

CCDS52284.1

UniProtKB/TrEMBL

E9Q4F9

Related

ENSMUSP00000095931.3, ENSMUST00000098326.3

Conserved Domains (2) summary

TIGR02168
Location:103 → 278

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:1 → 47

PH-like; Pleckstrin homology-like domain
NM_011983.2 → NP_036113.1 homer protein homolog 2 isoform 1

See identical proteins and their annotated locations for NP_036113.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC140366, AF093260, AK163423

Consensus CDS

CCDS40009.1

UniProtKB/Swiss-Prot

O89025, Q9QWW1, Q9Z0E4

Related

ENSMUSP00000146787.2, ENSMUST00000207983.2

Conserved Domains (2) summary

cd01206
Location:3 → 111

EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

TIGR02168
Location:167 → 342

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

81250229..81356673 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540909.1 → XP_006540972.1 homer protein homolog 2 isoform X1

See identical proteins and their annotated locations for XP_006540972.1

UniProtKB/TrEMBL

E9Q4F9

Conserved Domains (2) summary

TIGR02168
Location:103 → 278

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl17171
Location:1 → 47

PH-like; Pleckstrin homology-like domain
XM_030242611.2 → XP_030098471.1 homer protein homolog 2 isoform X2

Conserved Domains (2) summary

TIGR02169
Location:36 → 251

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cl17171
Location:1 → 47

PH-like; Pleckstrin homology-like domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177029.3: Suppressed sequence

Description

NM_177029.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.