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    Bcor BCL6 interacting corepressor [ Mus musculus (house mouse) ]

    Gene ID: 71458, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bcorprovided by MGI
    Official Full Name
    BCL6 interacting corepressorprovided by MGI
    Primary source
    MGI:MGI:1918708
    See related
    Ensembl:ENSMUSG00000040363 AllianceGenome:MGI:1918708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BcorR; mKIAA1575; 2900008C10Rik; 5830466J11Rik; 8430401K06Rik; D930024N20Rik
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Acts upstream of or within blastocyst hatching and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; eye; gonad; lung; and nervous system. Used to study syndromic microphthalmia 2. Human ortholog(s) of this gene implicated in dental caries; eye disease (multiple); and gastrointestinal system cancer (multiple). Orthologous to several human genes including BCOR (BCL6 corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 7.4), CNS E11.5 (RPKM 5.8) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bcor in Genome Data Viewer
    Location:
    X A1.1; X 6.83 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (11902976..12026769, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (12036737..12160516, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46728 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_46729 Neighboring gene STARR-seq mESC enhancer starr_46733 Neighboring gene predicted gene, 34301 Neighboring gene STARR-seq mESC enhancer starr_46737 Neighboring gene predicted gene, 46687 Neighboring gene STARR-seq mESC enhancer starr_46744 Neighboring gene STARR-seq mESC enhancer starr_46745 Neighboring gene elongin-B pseudogene Neighboring gene STARR-seq mESC enhancer starr_46747 Neighboring gene STARR-seq mESC enhancer starr_46751 Neighboring gene predicted gene 14635

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (5) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of BCOR complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of BCOR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168321.1NP_001161793.1  BCL-6 corepressor isoform d

      See identical proteins and their annotated locations for NP_001161793.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) has an alternate 5' UTR exon and lacks an exon and a segment in the CDS, as compared to variant a. The resulting isoform (d) lacks two internal segments, as compared to isoform a.
      Source sequence(s)
      AK129398, BC058656
      Consensus CDS
      CCDS30022.1
      UniProtKB/Swiss-Prot
      Q8CGN4
      Related
      ENSMUSP00000048024.7, ENSMUST00000043441.13
      Conserved Domains (5) summary
      cd00204
      Location:14091517
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:15821698
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:14191510
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11531365
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:14151446
      ANK; ANK repeat [structural motif]
    2. NM_029510.3NP_083786.2  BCL-6 corepressor isoform a

      See identical proteins and their annotated locations for NP_083786.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) encodes the longest isoform (a).
      Source sequence(s)
      AK053309, BC058656, CD563463
      Consensus CDS
      CCDS40873.1
      UniProtKB/Swiss-Prot
      B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4
      Related
      ENSMUSP00000111175.3, ENSMUST00000115513.9
      Conserved Domains (5) summary
      cd14261
      Location:16341750
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14671498
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14711562
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12051417
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    3. NM_175044.3NP_778209.2  BCL-6 corepressor isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) lacks an exon in the CDS, as compared to variant a. The resulting isoform (b) lacks an internal segment, as compared to isoform a.
      Source sequence(s)
      AK053309, BC058656, CD563463
      Consensus CDS
      CCDS40872.1
      UniProtKB/Swiss-Prot
      Q8CGN4
      Related
      ENSMUSP00000111174.3, ENSMUST00000115512.9
      Conserved Domains (5) summary
      cd14261
      Location:16161732
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14491480
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14531544
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11871399
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    4. NM_175045.3NP_778210.2  BCL-6 corepressor isoform c

      See identical proteins and their annotated locations for NP_778210.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) lacks a segment in the CDS, as compared to variant a. The resulting isoform (c) lacks an internal segment, as compared to isoform a.
      Source sequence(s)
      AK053309, BC058656
      Consensus CDS
      CCDS30021.1
      UniProtKB/Swiss-Prot
      Q8CGN4
      Related
      ENSMUSP00000068618.8, ENSMUST00000065143.14
      Conserved Domains (5) summary
      cd14261
      Location:16001716
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14331464
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14371528
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11711383
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    5. NM_175046.3NP_778211.2  BCL-6 corepressor isoform d

      See identical proteins and their annotated locations for NP_778211.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) lacks an exon and a segment in the CDS, as compared to variant a. The resulting isoform (d) lacks two internal segments, as compared to isoform a.
      Source sequence(s)
      AK053309, BC058656, CD563463
      Consensus CDS
      CCDS30022.1
      UniProtKB/Swiss-Prot
      Q8CGN4
      Related
      ENSMUSP00000116258.2, ENSMUST00000124033.8
      Conserved Domains (5) summary
      cd00204
      Location:14091517
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14261
      Location:15821698
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam12796
      Location:14191510
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11531365
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
      sd00045
      Location:14151446
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_045434.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (f) lacks several 3' exons and includes three alternate 3' exons. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC027704, BP776822
      Related
      ENSMUST00000209776.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      11902976..12026769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318623.3XP_017174112.1  BCL-6 corepressor isoform X2

      UniProtKB/Swiss-Prot
      B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4
      Conserved Domains (5) summary
      cd14261
      Location:16341750
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14671498
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14711562
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12051417
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    2. XM_036162096.1XP_036017989.1  BCL-6 corepressor isoform X4

      Conserved Domains (5) summary
      cd14261
      Location:16161732
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14491480
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14531544
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11871399
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    3. XM_017318621.3XP_017174110.1  BCL-6 corepressor isoform X2

      UniProtKB/Swiss-Prot
      B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4
      Conserved Domains (5) summary
      cd14261
      Location:16341750
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14671498
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14711562
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12051417
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    4. XM_036162097.1XP_036017990.1  BCL-6 corepressor isoform X4

      Conserved Domains (5) summary
      cd14261
      Location:16161732
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14491480
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14531544
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11871399
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    5. XM_017318622.2XP_017174111.1  BCL-6 corepressor isoform X2

      UniProtKB/Swiss-Prot
      B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4
      Conserved Domains (5) summary
      cd14261
      Location:16341750
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14671498
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14711562
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12051417
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    6. XM_030251500.1XP_030107360.1  BCL-6 corepressor isoform X3

      Conserved Domains (5) summary
      cd14261
      Location:16301746
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:271688
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14631494
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14671558
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12011413
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    7. XM_030251499.1XP_030107359.1  BCL-6 corepressor isoform X1

      Conserved Domains (5) summary
      cd14261
      Location:16481764
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:271688
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14811512
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14851576
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12191431
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    8. XM_017318624.3XP_017174113.1  BCL-6 corepressor isoform X2

      UniProtKB/Swiss-Prot
      B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4
      Conserved Domains (5) summary
      cd14261
      Location:16341750
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14671498
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14711562
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12051417
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    9. XM_036162095.1XP_036017988.1  BCL-6 corepressor isoform X2

      UniProtKB/Swiss-Prot
      B1AXK3, B1AXK4, B1AXK5, B1AXK6, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3, Q8CGN4
      Conserved Domains (5) summary
      cd14261
      Location:16341750
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14671498
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14711562
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:12051417
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    10. XM_036162099.1XP_036017992.1  BCL-6 corepressor isoform X6

      Conserved Domains (5) summary
      cd14261
      Location:16001716
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14331464
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14371528
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11711383
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    11. XM_036162098.1XP_036017991.1  BCL-6 corepressor isoform X6

      Conserved Domains (5) summary
      cd14261
      Location:16001716
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14331464
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14371528
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11711383
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    12. XM_030251502.2XP_030107362.1  BCL-6 corepressor isoform X6

      Conserved Domains (5) summary
      cd14261
      Location:16001716
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:257674
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14331464
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14371528
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11711383
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    13. XM_030251503.2XP_030107363.1  BCL-6 corepressor isoform X7

      Conserved Domains (5) summary
      cd14261
      Location:15961712
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:271688
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14291460
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14331524
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11671379
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region
    14. XM_030251501.2XP_030107361.1  BCL-6 corepressor isoform X5

      Conserved Domains (5) summary
      cd14261
      Location:16141730
      PUFD; PCGF Ub-like fold discriminator of BCOR
      pfam05109
      Location:271688
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00045
      Location:14471478
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:14511542
      Ank_2; Ankyrin repeats (3 copies)
      pfam15808
      Location:11851397
      BCOR; BCL-6 co-repressor, non-ankyrin-repeat region