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    Abhd17a abhydrolase domain containing 17A, depalmitoylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299617, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abhd17aprovided by RGD
    Official Full Name
    abhydrolase domain containing 17A, depalmitoylaseprovided by RGD
    Primary source
    RGD:1359682
    See related
    AllianceGenome:RGD:1359682
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam108a; upf0227; Fam108a1; RGD1359682
    Summary
    Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation; regulation of postsynapse organization; and regulation of protein localization. Located in plasma membrane; postsynaptic density; and recycling endosome membrane. Is active in glutamatergic synapse; postsynaptic density membrane; and postsynaptic recycling endosome membrane. Orthologous to human ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 94.8), Adrenal (RPKM 79.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Abhd17a in Genome Data Viewer
    Location:
    7q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9775016..9781447)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9124332..9132762)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11992543..12000978)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 4 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene adenosine deaminase, tRNA-specific 3 Neighboring gene KLF transcription factor 16 Neighboring gene uncharacterized LOC120093775 Neighboring gene RNA exonuclease 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. Lin DT, et al. Elife, 2015 Dec 23. PMID 26701913, Free PMC Article
    2. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, et al. Neuron, 2017 May 17. PMID 28521134
    3. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, et al. J Neurosci, 2016 Jun 15. PMID 27307232, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94549

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of NLRP3 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein depalmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein depalmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic recycling endosome membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha/beta hydrolase domain-containing protein 17A
    Names
    abhydrolase domain-containing protein 17A
    abhydrolase domain-containing protein FAM108A
    family with sequence similarity 108, member A1
    protein ABHD17A
    NP_001006984.1
    XP_008763312.1
    XP_063119243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006983.1 → NP_001006984.1  alpha/beta hydrolase domain-containing protein 17A

      See identical proteins and their annotated locations for NP_001006984.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083686
      UniProtKB/Swiss-Prot
      Q5XIJ5
      UniProtKB/TrEMBL
      A6K8J3, A6K8J4
      Conserved Domains (1) summary
      COG1073
      Location:113 → 305
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9775016..9781447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765090.4 → XP_008763312.1  alpha/beta hydrolase domain-containing protein 17A isoform X1

      See identical proteins and their annotated locations for XP_008763312.1

      UniProtKB/Swiss-Prot
      Q5XIJ5
      UniProtKB/TrEMBL
      A6K8J3, A6K8J4
      Conserved Domains (1) summary
      COG1073
      Location:113 → 305
      FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

    2. XM_063263173.1 → XP_063119243.1  alpha/beta hydrolase domain-containing protein 17A isoform X1

      UniProtKB/Swiss-Prot
      Q5XIJ5
      UniProtKB/TrEMBL
      A6K8J3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIJ5.1 GenPept UniProtKB/Swiss-Prot:Q5XIJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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