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    Adgrg3 adhesion G protein-coupled receptor G3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrg3provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor G3provided by RGD
    Primary source
    RGD:1305674
    See related
    EnsemblRapid:ENSRNOG00000014896 AllianceGenome:RGD:1305674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr97
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of CREB transcription factor activity; and negative regulation of non-canonical NF-kappaB signal transduction. Predicted to be active in plasma membrane. Orthologous to human ADGRG3 (adhesion G protein-coupled receptor G3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 11.6), Spleen (RPKM 8.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrg3 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9978450..10007145, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9972425..10001118, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10392001..10422606, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene katanin regulatory subunit B1 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene adhesion G protein-coupled receptor G5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gpr97 is essential for the follicular versus marginal zone B-lymphocyte fate decision. Wang JJ, et al. Cell Death Dis, 2013 Oct 10. PMID 24113187, Free PMC Article
    2. Signaling property study of adhesion G-protein-coupled receptors. Gupte J, et al. FEBS Lett, 2012 Apr 24. PMID 22575658
    3. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. Valtcheva N, et al. J Biol Chem, 2013 Dec 13. PMID 24178298, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 97; adhesion G protein-coupled receptor G3
    Names
    G protein-coupled receptor 97

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430216.1 → NP_001417145.1  probable G-protein coupled receptor 97 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2JSN6, A6JY31

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9978450..10007145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255127.5 → XP_006255189.1  adhesion G protein-coupled receptor G3 isoform X4

      See identical proteins and their annotated locations for XP_006255189.1

      UniProtKB/TrEMBL
      A6JY31
      Related
      ENSRNOP00000078552.2, ENSRNOT00000105448.2
      Conserved Domains (2) summary
      pfam01825
      Location:167 → 206
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:216 → 465
      7tm_4; Olfactory receptor

    2. XM_006255126.5 → XP_006255188.1  adhesion G protein-coupled receptor G3 isoform X2

      Related
      ENSRNOP00000020062.5, ENSRNOT00000020062.9
      Conserved Domains (2) summary
      pfam01825
      Location:216 → 255
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:265 → 514
      7tm_4; Olfactory receptor

    3. XM_039098149.1 → XP_038954077.1  adhesion G protein-coupled receptor G3 isoform X3

      UniProtKB/TrEMBL
      A6JY31
      Conserved Domains (3) summary
      pfam01825
      Location:195 → 233
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:245 → 270
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:243 → 502
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_039098148.1 → XP_038954076.1  adhesion G protein-coupled receptor G3 isoform X1

      UniProtKB/TrEMBL
      A6JY31
      Conserved Domains (3) summary
      pfam01825
      Location:244 → 282
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:294 → 319
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:292 → 551
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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