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    Gins3 GINS complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307639, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gins3provided by RGD
    Official Full Name
    GINS complex subunit 3provided by RGD
    Primary source
    RGD:1308153
    See related
    EnsemblRapid:ENSRNOG00000011863 AllianceGenome:RGD:1308153
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308153
    Summary
    Predicted to be involved in DNA unwinding involved in DNA replication and mitotic DNA replication initiation. Predicted to be located in nucleoplasm. Predicted to be part of CMG complex and GINS complex. Orthologous to human GINS3 (GINS complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 72.5), Spleen (RPKM 41.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gins3 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9426140..9435192, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9420085..9428621, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (9835113..9843649, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098501 Neighboring gene NDRG family member 4 Neighboring gene gem (nuclear organelle) associated protein 8, pseudogene 10 Neighboring gene uncharacterized LOC120098510 Neighboring gene serine protease 54 Neighboring gene coiled-coil domain containing 113

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication complex GINS protein PSF3
    Names
    GINS complex subunit 3 (Psf3 homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107408.1 → NP_001100878.1  DNA replication complex GINS protein PSF3

      See identical proteins and their annotated locations for NP_001100878.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474006
      UniProtKB/TrEMBL
      A6JY01, D3Z9I4
      Related
      ENSRNOP00000015795.3, ENSRNOT00000015795.7
      Conserved Domains (2) summary
      cd11713
      Location:83 → 192
      GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
      cd21693
      Location:19 → 89
      GINS_B_Psf3; beta-strand (B) domain of GINS complex protein Psf3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      9426140..9435192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277977.1 → XP_063134047.1  DNA replication complex GINS protein PSF3 isoform X1

      UniProtKB/TrEMBL
      A6JY01, D3Z9I4
    Nucleotide Protein Strain
    Heading Accession and Version

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