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    Rab6b RAB6B, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 270192, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rab6bprovided by MGI
    Official Full Name
    RAB6B, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:107283
    See related
    Ensembl:ENSMUSG00000032549 AllianceGenome:MGI:107283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9630015C03; D9Bwg0185e; C330006L04Rik
    Summary
    Predicted to enable GTPase activity and myosin V binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; protein localization to Golgi membrane; and retrograde transport, endosome to Golgi. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and presynapse. Is expressed in several structures, including gonad; nasal cavity epithelium; nervous system; neural retina; and spleen. Orthologous to human RAB6B (RAB6B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 50.6), frontal lobe adult (RPKM 45.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab6b in Genome Data Viewer
    Location:
    9 F1; 9 54.88 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102988866..103062475)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (103111667..103185276)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25080 Neighboring gene predicted gene, 31434 Neighboring gene solute carrier organic anion transporter family, member 2a1 Neighboring gene predicted gene, 22595 Neighboring gene STARR-seq mESC enhancer starr_25082 Neighboring gene STARR-positive B cell enhancer ABC_E8309 Neighboring gene predicted gene, 46128 Neighboring gene predicted gene, 51658 Neighboring gene STARR-positive B cell enhancer ABC_E6799 Neighboring gene signal recognition particle receptor, B subunit Neighboring gene transferrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection. Domínguez Cadena LC, et al. Immunol Cell Biol, 2021 Nov. PMID 34555867
    2. Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation. Zhang Y, et al. J Neurosci, 2024 Jul 3. PMID 38830762,
    3. ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals. Nyitrai H, et al. Cell Rep, 2020 Jun 9. PMID 32521280, Free PMC Article
    4. Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport. Monier S, et al. Traffic, 2002 Apr. PMID 11929610
    5. RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination. Brault JB, et al. EMBO Rep, 2022 Oct 6. PMID 35979738, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection.
      Title: Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin V binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-6B
    NP_776142.1
    XP_006511799.1
    XP_006511800.1
    XP_017168890.1
    XP_030100263.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173781.4 → NP_776142.1  ras-related protein Rab-6B

      See identical proteins and their annotated locations for NP_776142.1

      Status: PROVISIONAL

      Source sequence(s)
      AC156633
      Consensus CDS
      CCDS23449.1
      UniProtKB/Swiss-Prot
      P61294
      UniProtKB/TrEMBL
      Q0PD53
      Related
      ENSMUSP00000035155.7, ENSMUST00000035155.8
      Conserved Domains (1) summary
      cd01861
      Location:14 → 174
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      102988866..103062475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244403.1 → XP_030100263.1  ras-related protein Rab-6B isoform X3

    2. XM_006511737.3 → XP_006511800.1  ras-related protein Rab-6B isoform X2

      Conserved Domains (1) summary
      cd01861
      Location:21 → 170
      Rab6; Rab GTPase family 6 (Rab6)

    3. XM_017313401.1 → XP_017168890.1  ras-related protein Rab-6B isoform X4

      Conserved Domains (1) summary
      cl38936
      Location:50 → 69
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_006511736.5 → XP_006511799.1  ras-related protein Rab-6B isoform X1

      Conserved Domains (1) summary
      cd01861
      Location:50 → 200
      Rab6; Rab GTPase family 6 (Rab6)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61294.1 GenPept UniProtKB/Swiss-Prot:P61294

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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