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    Tlk1 tousled-like kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311118, updated on 9-Dec-2024

    Summary

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    Symbol
    Tlk1provided by RGD
    Full Name
    tousled-like kinase 1provided by RGD
    Primary source
    RGD:1310370
    See related
    EnsemblRapid:ENSRNOG00000009300 AllianceGenome:RGD:1310370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; protein phosphorylation; and regulation of chromatin organization. Predicted to be located in nucleoplasm. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 172.8), Spleen (RPKM 164.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tlk1 in Genome Data Viewer
    Location:
    3q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75928303..76035246, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55520559..55627580, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57012738..57376336, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486102 Neighboring gene uncharacterized LOC134486101 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene uncharacterized LOC120101562 Neighboring gene uncharacterized LOC134486287 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. Cabaniols JP, et al. Mol Biol Cell, 1999 Dec. PMID 10588641, Free PMC Article
    2. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. Groth A, et al. EMBO J, 2003 Apr 1. PMID 12660173, Free PMC Article
    3. Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication. Silljé HH, et al. EMBO J, 1999 Oct 15. PMID 10523312, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase tousled-like 1
    NP_001381947.1
    NP_001381948.1
    XP_008760119.1
    XP_008760121.1
    XP_038960783.1
    XP_038960784.1
    XP_063139694.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395018.1 → NP_001381947.1  serine/threonine-protein kinase tousled-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K920, A0A8I6AQ02
      Related
      ENSRNOP00000068174.3, ENSRNOT00000076281.4
      Conserved Domains (1) summary
      cd14040
      Location:449 → 747
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    2. NM_001395019.1 → NP_001381948.1  serine/threonine-protein kinase tousled-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A096MJL4
      Conserved Domains (1) summary
      cd14040
      Location:401 → 699
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      75928303..76035246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104855.2 → XP_038960783.1  serine/threonine-protein kinase tousled-like 1 isoform X2

      Conserved Domains (1) summary
      cd14040
      Location:232 → 530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    2. XM_008761897.4 → XP_008760119.1  serine/threonine-protein kinase tousled-like 1 isoform X1

      See identical proteins and their annotated locations for XP_008760119.1

      UniProtKB/TrEMBL
      A0A096MJL4
      Conserved Domains (1) summary
      cd14040
      Location:401 → 699
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    3. XM_008761899.4 → XP_008760121.1  serine/threonine-protein kinase tousled-like 1 isoform X1

      See identical proteins and their annotated locations for XP_008760121.1

      UniProtKB/TrEMBL
      A0A096MJL4
      Conserved Domains (1) summary
      cd14040
      Location:401 → 699
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    4. XM_063283624.1 → XP_063139694.1  serine/threonine-protein kinase tousled-like 1 isoform X2

    5. XM_039104856.2 → XP_038960784.1  serine/threonine-protein kinase tousled-like 1 isoform X2

      Conserved Domains (1) summary
      cd14040
      Location:232 → 530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    RNA

    1. XR_005501858.2 RNA Sequence

      Related
      ENSRNOT00000064203.4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107734.1: Suppressed sequence

      Description
      NM_001107734.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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