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    Arhgap44 Rho GTPase activating protein 44 [ Mus musculus (house mouse) ]

    Gene ID: 216831, updated on 3-Dec-2024

    Summary

    Official Symbol
    Arhgap44provided by MGI
    Official Full Name
    Rho GTPase activating protein 44provided by MGI
    Primary source
    MGI:MGI:2144423
    See related
    Ensembl:ENSMUSG00000033389 AllianceGenome:MGI:2144423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rich2; 6330543G20
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including negative regulation of Rac protein signal transduction; regulation of dendritic spine morphogenesis; and regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane. Located in dendritic spine. Is active in glutamatergic synapse. Is expressed in central nervous system; olfactory epithelium; respiratory system; and retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 17.6), frontal lobe adult (RPKM 14.1) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Arhgap44 in Genome Data Viewer
    Location:
    11 B3; 11 40.42 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (64892865..65053779, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (65002039..65162972, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30305 Neighboring gene STARR-seq mESC enhancer starr_29760 Neighboring gene predicted gene 12292 Neighboring gene predicted gene, 40025 Neighboring gene STARR-positive B cell enhancer ABC_E2356 Neighboring gene elaC ribonuclease Z 2 Neighboring gene STARR-seq mESC enhancer starr_29762 Neighboring gene STARR-seq mESC enhancer starr_29763 Neighboring gene RIKEN cDNA 1700086D15 gene Neighboring gene STARR-seq mESC enhancer starr_29766 Neighboring gene predicted gene, 53042 Neighboring gene VISTA enhancer mm67 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene myocardin Neighboring gene predicted gene, 30586

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in modification of dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in modification of postsynaptic structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of Rac protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in leading edge membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in leading edge membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in leading edge membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 44
    Names
    Rho GTPase-activating protein RICH2
    Rho-type GTPase-activating protein RICH2
    RhoGAP interacting with CIP4 homologs protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099288.2NP_001092758.1  rho GTPase-activating protein 44 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL663045
      UniProtKB/Swiss-Prot
      Q5SSM3
      Conserved Domains (3) summary
      cd07619
      Location:13260
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:249449
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl21455
      Location:553620
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_001408223.1NP_001395152.1  rho GTPase-activating protein 44 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663045
      UniProtKB/Swiss-Prot
      Q5SSM3, Q5SSM4, Q5SSM6, Q5SSM7, Q7TNB9, Q8BW90
      Related
      ENSMUSP00000090681.6, ENSMUST00000093002.12
    3. NM_001408224.1NP_001395153.1  rho GTPase-activating protein 44 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL663045
      UniProtKB/TrEMBL
      F6T1Y2
    4. NM_001408226.1NP_001395155.1  rho GTPase-activating protein 44 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL663045
    5. NM_001408228.1NP_001395157.1  rho GTPase-activating protein 44 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL663045
      UniProtKB/TrEMBL
      F6T1Y2
    6. NM_175003.4NP_778168.2  rho GTPase-activating protein 44 isoform 2

      See identical proteins and their annotated locations for NP_778168.2

      Status: VALIDATED

      Source sequence(s)
      AL663045
      Consensus CDS
      CCDS36180.1
      UniProtKB/TrEMBL
      F6T1Y2
      Related
      ENSMUSP00000039139.9, ENSMUST00000047463.15
      Conserved Domains (3) summary
      cd07619
      Location:13260
      BAR_Rich2; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 2
      cl02570
      Location:249449
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl21455
      Location:553620
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      64892865..65053779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245812.2XP_030101672.1  rho GTPase-activating protein 44 isoform X4

      UniProtKB/TrEMBL
      F6T1Y2
      Conserved Domains (3) summary
      PHA03247
      Location:436716
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:156356
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:1167
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006532874.5XP_006532937.1  rho GTPase-activating protein 44 isoform X4

      UniProtKB/TrEMBL
      F6T1Y2
      Related
      ENSMUSP00000115612.2, ENSMUST00000130420.8
      Conserved Domains (3) summary
      PHA03247
      Location:436716
      PHA03247; large tegument protein UL36; Provisional
      cl02570
      Location:156356
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:1167
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature