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    Evi5 ecotropic viral integration site 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Evi5provided by RGD
    Official Full Name
    ecotropic viral integration site 5provided by RGD
    Primary source
    RGD:2322879
    See related
    EnsemblRapid:ENSRNOG00000002039 AllianceGenome:RGD:2322879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in positive regulation of GTPase activity and retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Orthologous to human EVI5 (ecotropic viral integration site 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 358.4), Kidney (RPKM 235.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Evi5 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2020524..2166593)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1875601..2021678)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2892738..3038237)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene RuvB-like AAA ATPase 2, pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene 40S ribosomal protein S26-like Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene ribosomal protein L5 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene growth factor independent 1 transcriptional repressor Neighboring gene RNA polymerase II associated protein 2 Neighboring gene glomulin, FKBP associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article
    2. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ecotropic viral integration site 5 protein homolog
    Names
    rCG57228-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271410.1 → NP_001258339.1  ecotropic viral integration site 5 protein homolog

      See identical proteins and their annotated locations for NP_001258339.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6GMA4, A6KPH4, D3ZJN9
      Related
      ENSRNOP00000058347.4, ENSRNOT00000061630.6
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl11555
      Location:456 → 494
      DUF1129; Protein of unknown function (DUF1129)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      2020524..2166593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250525.5 → XP_006250587.1  ecotropic viral integration site 5 protein homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZM01, A0A8I6GMA4
      Conserved Domains (2) summary
      smart00164
      Location:160 → 368
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl11555
      Location:516 → 554
      DUF1129; Protein of unknown function (DUF1129)

    2. XM_006250523.4 → XP_006250585.3  ecotropic viral integration site 5 protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6GMA4
      Related
      ENSRNOP00000078953.2, ENSRNOT00000117301.2

    3. XM_006250526.4 → XP_006250588.3  ecotropic viral integration site 5 protein homolog isoform X4

      UniProtKB/TrEMBL
      A0A8I6GMA4

    4. XM_039091539.2 → XP_038947467.2  ecotropic viral integration site 5 protein homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6GMA4

    5. XM_006250527.4 → XP_006250589.3  ecotropic viral integration site 5 protein homolog isoform X5

      UniProtKB/TrEMBL
      A0A8I6GMA4
      Related
      ENSRNOP00000097247.1, ENSRNOT00000118584.2

    6. XM_006250528.4 → XP_006250590.3  ecotropic viral integration site 5 protein homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6GMA4

    7. XM_063272787.1 → XP_063128857.1  ecotropic viral integration site 5 protein homolog isoform X10

    8. XM_063272786.1 → XP_063128856.1  ecotropic viral integration site 5 protein homolog isoform X9

      UniProtKB/TrEMBL
      A0A8I6GMA4

    9. XM_063272785.1 → XP_063128855.1  ecotropic viral integration site 5 protein homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I6ASB5

    10. XM_039091540.2 → XP_038947468.1  ecotropic viral integration site 5 protein homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I6ASB5
      Conserved Domains (2) summary
      smart00164
      Location:116 → 324
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:348 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_006250533.5 → XP_006250595.1  ecotropic viral integration site 5 protein homolog isoform X8

      UniProtKB/TrEMBL
      A6KPH7
      Conserved Domains (2) summary
      smart00164
      Location:71 → 279
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl11555
      Location:427 → 465
      DUF1129; Protein of unknown function (DUF1129)

    12. XM_039091542.2 → XP_038947470.1  ecotropic viral integration site 5 protein homolog isoform X9

      UniProtKB/TrEMBL
      A0A8I6GMA4
      Conserved Domains (2) summary
      smart00164
      Location:2 → 187
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:211 → 556
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version

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