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    Nars1 asparaginyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291556, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nars1provided by RGD
    Official Full Name
    asparaginyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1307238
    See related
    EnsemblRapid:ENSRNOG00000017852 AllianceGenome:RGD:1307238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nars; LRRGT00113
    Summary
    Predicted to enable CCR3 chemokine receptor binding activity; asparagine-tRNA ligase activity; and protein dimerization activity. Predicted to be involved in asparaginyl-tRNA aminoacylation; cell migration; and cerebral cortex development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 412.4), Liver (RPKM 323.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nars1 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (60259506..60275782, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57989308..58005584, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59986350..60002644, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene one cut homeobox 2 Neighboring gene ferrochelatase Neighboring gene ATPase phospholipid transporting 8B1 Neighboring gene SPT2 chromatin protein domain containing 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity. Park JS, et al. Int J Biol Macromol, 2018 Dec. PMID 30171954
    2. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. Beaulande M, et al. Nucleic Acids Res, 1998 Jan 15. PMID 9421509, Free PMC Article
    3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    4. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116236

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CCR3 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables asparagine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparaginyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparaginyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    asparagine--tRNA ligase, cytoplasmic
    Names
    asparaginyl-tRNA synthetase, cytoplasmic
    NP_001020806.2
    NP_001136421.1
    NP_001385496.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025635.3 → NP_001020806.2  asparagine--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_001020806.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2JUE7, A6IXP1, F1LPV0
      Conserved Domains (3) summary
      COG0017
      Location:135 → 558
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00776
      Location:235 → 554
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04323
      Location:137 → 219
      AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

    2. NM_001142949.2 → NP_001136421.1  asparagine--tRNA ligase, cytoplasmic isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has several differences near the N-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      F1LML0, Q6TUD1
      Related
      ENSRNOP00000055935.2, ENSRNOT00000059162.6
      Conserved Domains (3) summary
      COG0017
      Location:84 → 507
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00776
      Location:184 → 503
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04323
      Location:86 → 168
      AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

    3. NM_001398567.1 → NP_001385496.1  asparagine--tRNA ligase, cytoplasmic isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      Related
      ENSRNOP00000024264.7, ENSRNOT00000024264.10
      Conserved Domains (1) summary
      COG0017
      Location:136 → 559
      AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      60259506..60275782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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