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    Abi2 abl interactor 2 [ Mus musculus (house mouse) ]

    Gene ID: 329165, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abi2provided by MGI
    Official Full Name
    abl interactor 2provided by MGI
    Primary source
    MGI:MGI:106913
    See related
    Ensembl:ENSMUSG00000026782 AllianceGenome:MGI:106913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AblBP3; ArgBP1; C130078H13; 8430425M24Rik
    Summary
    Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Involved in lens fiber cell morphogenesis; postsynaptic actin cytoskeleton organization; and regulation of dendritic spine morphogenesis. Acts upstream of or within camera-type eye development; generation of neurons; and learning or memory. Located in adherens junction and dendrite. Is active in dendritic spine; glutamatergic synapse; and postsynaptic actin cytoskeleton. Is expressed in several structures, including future brain; intestine smooth muscle circular layer; lens; nervous system; and trunk. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 18.9), CNS E18 (RPKM 17.1) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Abi2 in Genome Data Viewer
    Location:
    1 C2; 1 30.47 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60444927..60521104)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60405768..60481945)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neurobeachin like 1 Neighboring gene STARR-seq mESC enhancer starr_01063 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_01064 Neighboring gene STARR-seq mESC enhancer starr_01065 Neighboring gene cytochrome P450, family 20, subfamily a, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_01070 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene SEC61 translocon subunit gamma, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_01072 Neighboring gene predicted gene 11578

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC90836, MGC90855

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens fiber cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in postsynapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynaptic actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zonula adherens assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zonula adherens assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    abl interactor 2
    Names
    abelson interactor 2
    abi-2
    abl-binding protein 3
    arg-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198570.2NP_001185499.1  abl interactor 2 isoform 1

      See identical proteins and their annotated locations for NP_001185499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC158969
      Consensus CDS
      CCDS78593.1
      UniProtKB/TrEMBL
      Q6AXD2
      Related
      ENSMUSP00000140274.2, ENSMUST00000188618.7
      Conserved Domains (2) summary
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:452486
      SH3; Src Homology 3 domain superfamily
    2. NM_001198571.2NP_001185500.1  abl interactor 2 isoform 2

      See identical proteins and their annotated locations for NP_001185500.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC158969
      Consensus CDS
      CCDS78594.1
      UniProtKB/TrEMBL
      Q6AXH6
      Related
      ENSMUSP00000141068.2, ENSMUST00000189980.7
      Conserved Domains (2) summary
      cd11972
      Location:419479
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    3. NM_001404705.1NP_001391634.1  abl interactor 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC158969
    4. NM_001404706.1NP_001391635.1  abl interactor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC158969
    5. NM_001404707.1NP_001391636.1  abl interactor 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC158969
    6. NM_001404708.1NP_001391637.1  abl interactor 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC158969
    7. NM_001404709.1NP_001391638.1  abl interactor 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC158969
    8. NM_001404710.1NP_001391639.1  abl interactor 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC158969
    9. NM_001404711.1NP_001391640.1  abl interactor 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC158969
    10. NM_001404712.1NP_001391641.1  abl interactor 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC158969
    11. NM_001404713.1NP_001391642.1  abl interactor 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC158969
      UniProtKB/TrEMBL
      A0A087WPP8
      Related
      ENSMUSP00000139867.2, ENSMUST00000187709.7
    12. NM_001404714.1NP_001391643.1  abl interactor 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC158969
    13. NM_001404715.1NP_001391644.1  abl interactor 2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC158969
    14. NM_001404716.1NP_001391645.1  abl interactor 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC158969
    15. NM_001404717.1NP_001391646.1  abl interactor 2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC158969
    16. NM_001404718.1NP_001391647.1  abl interactor 2 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC158969
    17. NM_001404719.1NP_001391648.1  abl interactor 2 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC158969
    18. NM_001404720.1NP_001391649.1  abl interactor 2 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC158969
    19. NM_001404721.1NP_001391650.1  abl interactor 2 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC158969
    20. NM_198127.3NP_937760.1  abl interactor 2 isoform 3

      See identical proteins and their annotated locations for NP_937760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC158969
      Consensus CDS
      CCDS14991.1
      UniProtKB/Swiss-Prot
      P62484
      Related
      ENSMUSP00000058754.9, ENSMUST00000052332.15
      Conserved Domains (2) summary
      cd11972
      Location:385445
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      60444927..60521104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496080.4XP_006496143.1  abl interactor 2 isoform X13

      Conserved Domains (2) summary
      cd11972
      Location:420480
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    2. XM_006496085.4XP_006496148.1  abl interactor 2 isoform X21

      Conserved Domains (2) summary
      cd11972
      Location:391451
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    3. XM_017321240.2XP_017176729.1  abl interactor 2 isoform X2

      Conserved Domains (3) summary
      cd11972
      Location:480540
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:199414
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    4. XM_036165783.1XP_036021676.1  abl interactor 2 isoform X14

      Conserved Domains (2) summary
      cd11972
      Location:419479
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93156
      Abi_HHR; Abl-interactor HHR
    5. XM_036165799.1XP_036021692.1  abl interactor 2 isoform X24

      Conserved Domains (2) summary
      cd11972
      Location:371431
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93156
      Abi_HHR; Abl-interactor HHR
    6. XM_030255006.1XP_030110866.1  abl interactor 2 isoform X4

      Conserved Domains (3) summary
      cd11972
      Location:474534
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:263399
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    7. XM_030255012.1XP_030110872.1  abl interactor 2 isoform X11

      Conserved Domains (3) summary
      cd11972
      Location:426486
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:215351
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    8. XM_006496084.4XP_006496147.1  abl interactor 2 isoform X19

      UniProtKB/TrEMBL
      A0A087WRS3
      Related
      ENSMUSP00000140750.2, ENSMUST00000188594.7
      Conserved Domains (3) summary
      cd11972
      Location:397457
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:215342
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    9. XM_030255013.1XP_030110873.1  abl interactor 2 isoform X12

      Conserved Domains (3) summary
      cd11972
      Location:425485
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:214350
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93163
      Abi_HHR; Abl-interactor HHR
    10. XM_036165790.1XP_036021683.1  abl interactor 2 isoform X20

      Conserved Domains (3) summary
      cd11972
      Location:396456
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:214341
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93156
      Abi_HHR; Abl-interactor HHR
    11. XM_036165801.1XP_036021694.1  abl interactor 2 isoform X26

      Conserved Domains (2) summary
      cd11972
      Location:364424
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93156
      Abi_HHR; Abl-interactor HHR
    12. XM_017321247.2XP_017176736.1  abl interactor 2 isoform X18

      Conserved Domains (3) summary
      cd11972
      Location:402462
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:220347
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR