S1pr2 sphingosine-1-phosphate receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S1pr2provided by MGI
Official Full Name: sphingosine-1-phosphate receptor 2provided by MGI
Primary source: MGI:MGI:99569
See related: Ensembl:ENSMUSG00000043895 AllianceGenome:MGI:99569
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Edg5; H218; LPb2; S1P2; Gpcr13; 1100001A16Rik
Summary: Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation; regulation of postsynapse assembly; and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 19.6), limb E14.5 (RPKM 17.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A3; 9 7.68 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (20877248..20888089, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (20965952..20976793, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflammasome activation, and pyroptosis.
Title: A detrimental role of endothelial S1PR2 in cardiac ischemia-reperfusion injury via modulating mitochondrial dysfunction, NLRP3 inflammasome activation, and pyroptosis.
S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis.
Title: S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis.
Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity.
Title: Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity.
S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway.
Title: S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway.
The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina Light Responses.
Title: The Role of Sphingosine-1-Phosphate Receptor 2 in Mouse Retina Light Responses.
S1PR2 Regulates Autophagy Through the AKT/mTOR Pathway to Promote Pathological Damage in Alzheimer's Disease.
Title: S1PR2 Regulates Autophagy Through the AKT/mTOR Pathway to Promote Pathological Damage in Alzheimer's Disease.
Inhibition of Sphingosine-1-Phosphate Receptor 2 by JTE013 Enhanced Alveolar Bone Regeneration by Promoting Angiogenesis.
Title: Inhibition of Sphingosine-1-Phosphate Receptor 2 by JTE013 Enhanced Alveolar Bone Regeneration by Promoting Angiogenesis.
Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice.
Title: Opposing Roles of Sphingosine 1-Phosphate Receptors 1 and 2 in Fat Deposition and Glucose Tolerance in Obese Male Mice.
Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic inflammatory responses via NF-kappa B activation in acute pancreatitis.
Title: Sphingosine 1-phosphate receptor 2 mediated early stages of pancreatic and systemic inflammatory responses via NF-kappa B activation in acute pancreatitis.
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.
Title: Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Spontaneous (1) 1 citation
Targeted (7) 1 citation

General gene information

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Markers

UniSTS:474719 (e-PCR)
- UniSTS:474719

Edg5 (e-PCR), detects polymorphism
- UniSTS:474719

Edg5 (e-PCR), detects polymorphism
- UniSTS:496525

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 2

Names: G-protein coupled receptor 13; S1P receptor 2; S1P receptor Edg-5; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5; lysophospholipid receptor B2; sphingosine 1-phosphate receptor Edg-5; sphingosine-1-phosphate receptor S1P(2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010333.4 → NP_034463.2 sphingosine 1-phosphate receptor 2

See identical proteins and their annotated locations for NP_034463.2

Status: VALIDATED

Source sequence(s)

AK151062, BY095108

Consensus CDS

CCDS22888.1

UniProtKB/Swiss-Prot

P52592, Q8C3Q7, Q9R236

UniProtKB/TrEMBL

Q3U5W6

Related

ENSMUSP00000053394.6, ENSMUST00000054197.7

Conserved Domains (2) summary

cd14964
Location:36 → 60

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:35 → 299

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

20877248..20888089 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510019.5 → XP_006510082.1 sphingosine 1-phosphate receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006510082.1

UniProtKB/Swiss-Prot

P52592, Q8C3Q7, Q9R236

UniProtKB/TrEMBL

Q3U5W6

Conserved Domains (2) summary

cd14964
Location:36 → 60

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:35 → 299

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily