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    Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 [ Mus musculus (house mouse) ]

    Gene ID: 330953, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hcn4provided by MGI
    Official Full Name
    hyperpolarization-activated, cyclic nucleotide-gated K+ 4provided by MGI
    Primary source
    MGI:MGI:1298209
    See related
    Ensembl:ENSMUSG00000032338 AllianceGenome:MGI:1298209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hcn3; Bcng3
    Summary
    Enables intracellularly cAMP-activated cation channel activity. Acts upstream of or within in utero embryonic development; monoatomic cation transport; and regulation of heart contraction. Located in axon. Is expressed in several structures, including eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 4.8), CNS E14 (RPKM 3.6) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Hcn4 in Genome Data Viewer
    Location:
    9 B; 9 31.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58730232..58770458)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58822949..58863175)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene REC114 meiotic recombination protein Neighboring gene predicted gene 20620 Neighboring gene STARR-seq mESC enhancer starr_24285 Neighboring gene predicted gene, 21183 Neighboring gene VISTA enhancer mm1997 Neighboring gene STARR-seq mESC enhancer starr_24288 Neighboring gene neogenin Neighboring gene STARR-seq mESC enhancer starr_24289 Neighboring gene STARR-seq mESC enhancer starr_24290 Neighboring gene STARR-seq mESC enhancer starr_24291 Neighboring gene ribosomal protein S10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables intracellularly cAMP-activated cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables intracellularly cAMP-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables voltage-gated potassium channel activity involved in SA node cell action potential depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cAMP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to cGMP ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane depolarization during SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of HCN channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of HCN channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Names
    brain cyclic nucleotide-gated channel 3
    hyperpolarization-activated, cyclic nucleotide-gated K+ 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081192.3NP_001074661.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

      See identical proteins and their annotated locations for NP_001074661.1

      Status: VALIDATED

      Source sequence(s)
      AC110530
      Consensus CDS
      CCDS52815.1
      UniProtKB/Swiss-Prot
      B2RY58, O70507
      Related
      ENSMUSP00000034889.9, ENSMUST00000034889.10
      Conserved Domains (4) summary
      COG0664
      Location:589724
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:595703
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:280525
      Ion_trans; Ion transport protein
      pfam08412
      Location:218260
      Ion_trans_N; Ion transport protein N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      58730232..58770458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)