Krt5 keratin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt5provided by MGI
Official Full Name: keratin 5provided by MGI
Primary source: MGI:MGI:96702
See related: Ensembl:ENSMUSG00000061527 AllianceGenome:MGI:96702
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K5; CK5; Tfip8; Krt2-5; 3300001P10Rik
Summary: Predicted to enable scaffold protein binding activity. Predicted to be a structural constituent of skin epidermis. Involved in several processes, including intermediate filament polymerization; regulation of cell migration; and response to mechanical stimulus. Located in cytoplasm; keratin filament; and plasma membrane. Is active in cornified envelope. Is expressed in several structures, including alimentary system; epithelium; genitourinary system; integumental system; and sensory organ. Used to study epidermolysis bullosa simplex Dowling-Meara type. Human ortholog(s) of this gene implicated in Dowling-Degos disease; epidermolysis bullosa simplex; and epidermolysis bullosa simplex with mottled pigmentation. Orthologous to human KRT5 (keratin 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 193.4), limb E14.5 (RPKM 123.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 56.98 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101615504..101621340, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101707069..101712905, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratin 5 basal cells are temporally regulated developmental and tissue repair progenitors in bladder urothelium.
Title: Keratin 5 basal cells are temporally regulated developmental and tissue repair progenitors in bladder urothelium.
Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.
Title: Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.
Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.
Title: Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression.
Krt5(+) renal urothelial cells drive renal urothelial formation during normal ontogeny and after urinary tract obstruction by differentiating into Upk(+) RUCs in a temporally restricted manner.
Title: Krt5(+) urothelial cells are developmental and tissue repair progenitors in the kidney.
We demonstrate using lineage-tracing systems that urothelial regeneration following augmentation cystoplasty with acellular grafts exclusively depends on host keratin 5-expressing basal cells to repopulate all lineages of the de novo urothelium at implant sites
Title: Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair.
CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14.
Title: Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase.
Taken together, our data demonstrated that Krt5-expressing cells could be involved in the natural pancreas self-healing process and the renewal of beta cells after AP in adult mice. It is promising that promoting conversion of Krt5-expressing cells into functional beta cells may be a novel method to mitigate the development of diabetes mellitus after AP in vivo.
Title: β cells can be generated from cytokeratin 5-positive cells after cerulein-induced pancreatitis in adult mice.
RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling.
Title: Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium.
widespread destruction of airway and alveolar epithelial cells following severe influenza infection triggers a wound-healing response that initiates in the airways with the proliferation of rare airway-resident SOX2+ Lin- progenitor cells. These cells then give rise to nascent KRT5+ cells in remodeled airways and populate the damaged alveolar parenchyma.
Title: Rare SOX2(+) Airway Progenitor Cells Generate KRT5(+) Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.
Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells.
Title: Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Krt2-5 (e-PCR), detects polymorphism
- UniSTS:265262

AW146334 (e-PCR)
- UniSTS:180846

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of skin epidermis	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in keratinization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: keratin, type II cytoskeletal 5

Names: 58 kDa cytokeratin; cytokeratin 5; keratin complex 2, basic, gene 5; tuftelin interacting protein 8; type-II keratin Kb5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027011.3 → NP_081287.1 keratin, type II cytoskeletal 5

See identical proteins and their annotated locations for NP_081287.1

Status: VALIDATED

Source sequence(s)

AC104862, AC120787

Consensus CDS

CCDS27861.1

UniProtKB/Swiss-Prot

Q920F2, Q922U2

UniProtKB/TrEMBL

Q32P04

Related

ENSMUSP00000023709.6, ENSMUST00000023709.7

Conserved Domains (3) summary

pfam00038
Location:161 → 474

Filament; Intermediate filament protein

pfam16208
Location:16 → 158

Keratin_2_head; Keratin type II head

cl01888
Location:387 → 447

DUF883; Bacterial protein of unknown function (DUF883)