Eml4 echinoderm microtubule associated protein like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eml4provided by MGI
Official Full Name: echinoderm microtubule associated protein like 4provided by MGI
Primary source: MGI:MGI:1926048
See related: Ensembl:ENSMUSG00000032624 AllianceGenome:MGI:1926048
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930443C24Rik
Summary: Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and microtubule binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in mitotic spindle. Is expressed in several structures, including alimentary system; limb; liver; nervous system; and retina. Orthologous to human EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.0), CNS E14 (RPKM 14.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 52.69 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (83658341..83787790)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (83350930..83480361)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI644019 (e-PCR)
- UniSTS:181071

WI-14803 (e-PCR)
- UniSTS:81072

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in attachment of spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: echinoderm microtubule-associated protein-like 4

Names: EMAP-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114361.1 → NP_001107833.1 echinoderm microtubule-associated protein-like 4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC164634, AC167969

Consensus CDS

CCDS50192.1

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

UniProtKB/TrEMBL

F8WJ93

Related

ENSMUSP00000094528.5, ENSMUST00000096766.12

Conserved Domains (6) summary

COG2319
Location:304 → 753

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:236 → 307

HELP; HELP motif

pfam15794
Location:21 → 131

CCDC106; Coiled-coil domain-containing protein 106

pfam16228
Location:112 → 234

DUF4887; Domain of unknown function (DUF4887)

sd00039
Location:649 → 684

7WD40; WD40 repeat [structural motif]

cl02567
Location:514 → 874

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001114362.1 → NP_001107834.1 echinoderm microtubule-associated protein-like 4 isoform 2

See identical proteins and their annotated locations for NP_001107834.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (2) lacks two internal segments, compared to isoform 1.

Source sequence(s)

AC164634, AC167969, BC070427

Consensus CDS

CCDS50193.1

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

UniProtKB/TrEMBL

A0A0R4J1G7

Related

ENSMUSP00000107982.3, ENSMUST00000112363.10

Conserved Domains (4) summary

COG2319
Location:235 → 684

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:167 → 238

HELP; HELP motif

sd00039
Location:580 → 615

7WD40; WD40 repeat [structural motif]

cl02567
Location:445 → 805

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001286567.1 → NP_001273496.1 echinoderm microtubule-associated protein-like 4 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an additional exon in the 5' region which results in translation initiation at an alternate start codon, and also lacks an in-frame internal coding exon, compared to variant 1. The resulting isoform (4) has a distinct N-terminus and lacks an internal segment, compared to isoform 1.

Source sequence(s)

AC167969, BC065178, BC066099, BC067011, DQ230326

Consensus CDS

CCDS89165.1

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

UniProtKB/TrEMBL

A0A3Q4EHV9

Related

ENSMUSP00000157143.2, ENSMUST00000234460.2

Conserved Domains (4) summary

sd00039
Location:602 → 637

7WD40; WD40 repeat [structural motif]

pfam03451
Location:189 → 260

HELP; HELP motif

cd21950
Location:20 → 75

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:467 → 827

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001357886.1 → NP_001344815.1 echinoderm microtubule-associated protein-like 4 isoform 5

Status: VALIDATED

Source sequence(s)

AC164634, AC167969, BC067011

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:548 → 583

7WD40; WD40 repeat [structural motif]

pfam03451
Location:135 → 206

HELP; HELP motif

cl25539
Location:413 → 773

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001379373.1 → NP_001366302.1 echinoderm microtubule-associated protein-like 4 isoform 6

Status: VALIDATED

Source sequence(s)

AC164634, AC167969

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

UniProtKB/TrEMBL

A7ISP9

Related

ENSMUSP00000157195.2, ENSMUST00000234584.2

Conserved Domains (4) summary

sd00039
Location:638 → 673

7WD40; WD40 repeat [structural motif]

pfam03451
Location:225 → 296

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:503 → 863

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001379374.1 → NP_001366303.1 echinoderm microtubule-associated protein-like 4 isoform 7

Status: VALIDATED

Source sequence(s)

AC164634, AC167969

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (4) summary

sd00039
Location:591 → 626

7WD40; WD40 repeat [structural motif]

pfam03451
Location:178 → 249

HELP; HELP motif

cd21950
Location:6 → 64

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:456 → 816

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_199466.3 → NP_955760.3 echinoderm microtubule-associated protein-like 4 isoform 3

See identical proteins and their annotated locations for NP_955760.3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three coding exons but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.

Source sequence(s)

AC167969, BC066099, BC067011

Consensus CDS

CCDS37708.1

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

UniProtKB/TrEMBL

A0A0R4J0H0

Related

ENSMUSP00000041880.9, ENSMUST00000049503.10

Conserved Domains (4) summary

COG2319
Location:192 → 641

WD40; WD40 repeat [General function prediction only]

pfam03451
Location:124 → 195

HELP; HELP motif

sd00039
Location:537 → 572

7WD40; WD40 repeat [structural motif]

cl02567
Location:402 → 762

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

83658341..83787790

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250148.2 → XP_030106008.1 echinoderm microtubule-associated protein-like 4 isoform X7

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:584 → 619

7WD40; WD40 repeat [structural motif]

pfam03451
Location:171 → 242

HELP; HELP motif

cl29593
Location:449 → 809

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525155.4 → XP_006525218.1 echinoderm microtubule-associated protein-like 4 isoform X1

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:660 → 695

7WD40; WD40 repeat [structural motif]

pfam03451
Location:247 → 318

HELP; HELP motif

cl29593
Location:525 → 885

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525157.4 → XP_006525220.1 echinoderm microtubule-associated protein-like 4 isoform X3

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:649 → 684

7WD40; WD40 repeat [structural motif]

pfam03451
Location:236 → 307

HELP; HELP motif

cl29593
Location:514 → 874

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525158.4 → XP_006525221.1 echinoderm microtubule-associated protein-like 4 isoform X4

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:602 → 637

7WD40; WD40 repeat [structural motif]

pfam03451
Location:189 → 260

HELP; HELP motif

cl29593
Location:467 → 827

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525161.4 → XP_006525224.1 echinoderm microtubule-associated protein-like 4 isoform X6

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:591 → 626

7WD40; WD40 repeat [structural motif]

pfam03451
Location:178 → 249

HELP; HELP motif

cl29593
Location:456 → 816

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525162.4 → XP_006525225.1 echinoderm microtubule-associated protein-like 4 isoform X8

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:559 → 594

7WD40; WD40 repeat [structural motif]

pfam03451
Location:146 → 217

HELP; HELP motif

cl29593
Location:424 → 784

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525163.4 → XP_006525226.1 echinoderm microtubule-associated protein-like 4 isoform X9

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:548 → 583

7WD40; WD40 repeat [structural motif]

pfam03451
Location:135 → 206

HELP; HELP motif

cl29593
Location:413 → 773

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036160850.1 → XP_036016743.1 echinoderm microtubule-associated protein-like 4 isoform X7

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:584 → 619

7WD40; WD40 repeat [structural motif]

pfam03451
Location:171 → 242

HELP; HELP motif

cl29593
Location:449 → 809

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006525156.5 → XP_006525219.1 echinoderm microtubule-associated protein-like 4 isoform X2

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

Conserved Domains (3) summary

sd00039
Location:660 → 695

7WD40; WD40 repeat [structural motif]

pfam03451
Location:247 → 318

HELP; HELP motif

cl29593
Location:525 → 885

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036160849.1 → XP_036016742.1 echinoderm microtubule-associated protein-like 4 isoform X5

UniProtKB/Swiss-Prot

Q3UMY5, Q6NS73, Q6NXL8, Q6NZJ8, Q6P1A7

UniProtKB/TrEMBL

A0A3Q4EHV9

Conserved Domains (4) summary

sd00039
Location:602 → 637

7WD40; WD40 repeat [structural motif]

pfam03451
Location:189 → 260

HELP; HELP motif

cd21950
Location:20 → 75

TD_EMAP4; trimerization domain of echinoderm microtubule-associated protein-like 4

cl29593
Location:467 → 827

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036160851.1 → XP_036016744.1 echinoderm microtubule-associated protein-like 4 isoform X10

Conserved Domains (3) summary

sd00039
Location:443 → 478

7WD40; WD40 repeat [structural motif]

pfam03451
Location:30 → 101

HELP; HELP motif

cl29593
Location:308 → 668

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011246732.3 → XP_011245034.1 echinoderm microtubule-associated protein-like 4 isoform X11

Conserved Domains (3) summary

sd00039
Location:410 → 445

7WD40; WD40 repeat [structural motif]

pfam03451
Location:1 → 68

HELP; HELP motif

cl29593
Location:275 → 635

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...