Mid1ip1 Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mid1ip1provided by MGI
Official Full Name: Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))provided by MGI
Primary source: MGI:MGI:1915291
See related: Ensembl:ENSMUSG00000008035 AllianceGenome:MGI:1915291
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S14R; Mig12; 3110038L01Rik
Summary: Enables identical protein binding activity. Involved in positive regulation of fatty acid biosynthetic process; positive regulation of ligase activity; and protein polymerization. Acts upstream of or within negative regulation of microtubule depolymerization. Located in cytosol; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; limb segment; and nervous system. Orthologous to human MID1IP1 (MID1 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 87.4), lung adult (RPKM 68.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 5.4 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (10583604..10585941)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (10717365..10719702)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIG12 is a mediator for stimulation of lipogenesis by LXR activation in the liver
Title: Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
the S14-R protein is a compensatory factor, at least partially responsible for the normal liver lipogenesis observed in the S14 null mouse
Title: Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate.
Mig12 is expressed in the embryonic ventral midline and co-operates with Mid1 to stabilize microtubules
Title: Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ligase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of lipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mid1-interacting protein 1

Names: gastrulation-specific G12-like protein; mid1-interacting G12-like protein; protein STRAIT11499 homolog; spot 14-R; spot 14-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166635.1 → NP_001160107.1 mid1-interacting protein 1

See identical proteins and their annotated locations for NP_001160107.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL671335

Consensus CDS

CCDS30018.1

UniProtKB/Swiss-Prot

Q8BHT5, Q9CQ20

UniProtKB/TrEMBL

Q4FK31

Related

ENSMUSP00000111186.2, ENSMUST00000115524.8

Conserved Domains (1) summary

pfam07084
Location:3 → 176

Spot_14; Thyroid hormone-inducible hepatic protein Spot 14
NM_026524.4 → NP_080800.1 mid1-interacting protein 1

See identical proteins and their annotated locations for NP_080800.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AL671335

Consensus CDS

CCDS30018.1

UniProtKB/Swiss-Prot

Q8BHT5, Q9CQ20

UniProtKB/TrEMBL

Q4FK31

Related

ENSMUSP00000008179.7, ENSMUST00000008179.7

Conserved Domains (1) summary

pfam07084
Location:3 → 176

Spot_14; Thyroid hormone-inducible hepatic protein Spot 14