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    H2-T22 histocompatibility 2, T region locus 22 [ Mus musculus (house mouse) ]

    Gene ID: 15039, updated on 27-Nov-2024

    Summary

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    Official Symbol
    H2-T22provided by MGI
    Official Full Name
    histocompatibility 2, T region locus 22provided by MGI
    Primary source
    MGI:MGI:95956
    See related
    Ensembl:ENSMUSG00000056116 AllianceGenome:MGI:95956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    27b; T22b; H-2T9; H2-T9; H-2T17; H-2T22; H2-T17
    Summary
    Predicted to enable several functions, including 14-3-3 protein binding activity; TAP binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including bounding membrane of organelle; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 85.3), subcutaneous fat pad adult (RPKM 74.4) and 22 other tissues See more
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    Genomic context

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    See H2-T22 in Genome Data Viewer
    Location:
    17 B1; 17 18.87 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36348023..36353635, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36037128..36042742, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930015D03 gene Neighboring gene histocompatibility 2, T region locus 24 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36157683-36157870 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:36160698-36160881 Neighboring gene STARR-positive B cell enhancer ABC_E8675 Neighboring gene histocompatibility 2, T region locus 23 Neighboring gene STARR-positive B cell enhancer ABC_E168 Neighboring gene predicted gene 6034 Neighboring gene predicted gene, 54001 Neighboring gene histocompatibility 2, D region locus 1 pseudogene Neighboring gene histocompatibility 2, T region locus 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antigen-presenting cells for naive transgenic gamma delta T cells. Potent activation by activated alpha beta T cells. Spaner D, et al. J Immunol, 1995 Oct 15. PMID 7561093
    2. Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain. Liu J, et al. Neurochem Res, 2015 Jul. PMID 26040564
    3. Role of a selecting ligand in shaping the murine γδ-TCR repertoire. Fahl SP, et al. Proc Natl Acad Sci U S A, 2018 Feb 20. PMID 29432160, Free PMC Article
    4. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Adams EJ, et al. Science, 2005 Apr 8. PMID 15821084
    5. A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types. Transy C, et al. J Exp Med, 1987 Aug 1. PMID 3036997, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC49483

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CD8 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP2 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-2-microglobulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables natural killer cell lectin-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class Ib protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histocompatibility 2, T region locus 22
    Names
    MHC classIb T22
    histocompatibility 2, T region locus 17
    histocompatibility 2, T region locus 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347382.2 → NP_001334311.1  histocompatibility 2, T region locus 22 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112970
      Consensus CDS
      CCDS84308.1
      UniProtKB/TrEMBL
      A7VMS4, Q9BCZ1
      Related
      ENSMUSP00000056041.8, ENSMUST00000058801.15
      Conserved Domains (2) summary
      cd07698
      Location:195 → 286
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:29 → 191
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. NM_001359754.2 → NP_001346683.1  histocompatibility 2, T region locus 22 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112970
      UniProtKB/TrEMBL
      A7VMS4
      Conserved Domains (2) summary
      cd07698
      Location:137 → 229
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:2 → 133
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    3. NM_001359755.2 → NP_001346684.1  histocompatibility 2, T region locus 22 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112970
      Consensus CDS
      CCDS37608.1
      UniProtKB/TrEMBL
      A7VMS4, Q31615
      Related
      ENSMUSP00000077111.7, ENSMUST00000077960.7
      Conserved Domains (2) summary
      cd07698
      Location:195 → 287
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:29 → 191
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    4. NM_001359756.2 → NP_001346685.1  histocompatibility 2, T region locus 22 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC112970
      Consensus CDS
      CCDS84308.1
      UniProtKB/TrEMBL
      A7VMS4, Q9BCZ1
      Related
      ENSMUST00000172633.8
      Conserved Domains (2) summary
      cd07698
      Location:195 → 286
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:29 → 191
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    5. NM_010397.6 → NP_034527.1  histocompatibility 2, T region locus 22 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034527.1

      Status: VALIDATED

      Source sequence(s)
      AC112970
      Consensus CDS
      CCDS37608.1
      UniProtKB/TrEMBL
      A7VMS4, Q31615
      Related
      ENSMUSP00000078927.6, ENSMUST00000080015.12
      Conserved Domains (2) summary
      cd07698
      Location:195 → 287
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:29 → 191
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36348023..36353635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_010396.2: Suppressed sequence

      Description
      NM_010396.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein Strain
    Heading Accession and Version

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