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    Etfrf1 electron transfer flavoprotein regulatory factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 67636, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Etfrf1provided by MGI
    Official Full Name
    electron transfer flavoprotein regulatory factor 1provided by MGI
    Primary source
    MGI:MGI:1914886
    See related
    Ensembl:ENSMUSG00000040370 AllianceGenome:MGI:1914886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ghiso; Lyrm5; 4930469P12Rik
    Summary
    Predicted to be involved in respiratory electron transport chain. Located in mitochondrion. Is expressed in adrenal medulla. Orthologous to human ETFRF1 (electron transfer flavoprotein regulatory factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.6), liver E18 (RPKM 9.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Etfrf1 in Genome Data Viewer
    Location:
    6 G3; 6 77.37 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145156860..145162891)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145211134..145217368)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene predicted gene 15543 Neighboring gene STARR-seq mESC enhancer starr_17780 Neighboring gene Kirsten rat sarcoma viral oncogene homolog Neighboring gene predicted gene 15706 Neighboring gene ribosomal protein S25, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Allelic effects of mouse Pas1 candidate genes in human lung cancer cell lines. Galbiati F, et al. Cancer Lett, 2006 Dec 8. PMID 16458428
    2. Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14583591, Free PMC Article
    3. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Nathan BM, et al. Endocrinology, 2006 Nov. PMID 16873534
    4. Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Manenti G, et al. Oncogene, 2004 May 27. PMID 15064703
    5. Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Wang M, et al. Cancer Res, 2003 Jun 15. PMID 12810665

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ghiso is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.
      Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in respiratory electron transport chain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    electron transfer flavoprotein regulatory factor 1
    Names
    LYR motif containing 5
    LYR motif-containing protein 5
    growth hormone-inducible soluble protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163628.1 → NP_001157100.1  electron transfer flavoprotein regulatory factor 1

      See identical proteins and their annotated locations for NP_001157100.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091, CX203242
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Related
      ENSMUSP00000107354.2, ENSMUST00000111725.8
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    2. NM_001362053.1 → NP_001348982.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the logest transcript. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    3. NM_001362054.1 → NP_001348983.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    4. NM_001362055.1 → NP_001348984.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Related
      ENSMUSP00000107350.2, ENSMUST00000111721.2
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    5. NM_001362056.1 → NP_001348985.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091, AF412298
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Related
      ENSMUSP00000039433.4, ENSMUST00000039729.5
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    6. NM_001362057.1 → NP_001348986.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091, AF412299
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Related
      ENSMUSP00000107353.2, ENSMUST00000111724.8
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    7. NM_001362058.1 → NP_001348987.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Related
      ENSMUSP00000107348.2, ENSMUST00000111719.2
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    8. NM_001362059.1 → NP_001348988.1  electron transfer flavoprotein regulatory factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 3. Variants 1-9 all encode the same protein.
      Source sequence(s)
      AC157091
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    9. NM_133688.3 → NP_598449.1  electron transfer flavoprotein regulatory factor 1

      See identical proteins and their annotated locations for NP_598449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC157091, AF412300, AK075835
      Consensus CDS
      CCDS39706.1
      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Related
      ENSMUSP00000107355.4, ENSMUST00000111726.10
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    RNA

    1. NR_155281.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) uses an alternate splice juinction and lacks an alternate exon compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC157091, BE848706

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      145156860..145162891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152279.1 → XP_036008172.1  electron transfer flavoprotein regulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Related
      ENSMUSP00000107352.2, ENSMUST00000111723.8
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    2. XM_006506983.5 → XP_006507046.1  electron transfer flavoprotein regulatory factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006507046.1

      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins

    3. XM_036152278.1 → XP_036008171.1  electron transfer flavoprotein regulatory factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2KFC1, Q675B1, Q8VDL7, Q91V16
      Conserved Domains (1) summary
      cd20265
      Location:6 → 79
      Complex1_LYR_ETFRF1_LYRM5; LYR (leucine-tyrosine-arginine) motif found in electron transfer flavoprotein regulatory factor 1 (ETFRF1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91V16.1 GenPept UniProtKB/Swiss-Prot:Q91V16

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