Tlk2 tousled-like kinase 2 (Arabidopsis) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlk2provided by MGI
Official Full Name: tousled-like kinase 2 (Arabidopsis)provided by MGI
Primary source: MGI:MGI:1346023
See related: Ensembl:ENSMUSG00000020694 AllianceGenome:MGI:1346023
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tlk; PKUalpha; PKU-alpha; 4933403M19Rik
Summary: Predicted to enable ATP binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Located in intermediate filament; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 7.8), CNS E11.5 (RPKM 5.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.61 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (105066869..105174785)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (105167895..105283959)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLK1 and TLK2 have largely redundant roles in genome maintenance.
Title: Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI840954 (e-PCR)
- UniSTS:165804

SHGC-57386 (e-PCR)
- UniSTS:29378

TLK2_8170 (e-PCR)
- UniSTS:467939

RH47409 (e-PCR)
- UniSTS:83944

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleus localization	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase tousled-like 2

Names: protein kinase U-alpha

NP_001106176.1

EC 2.7.11.1

NP_001281258.1

EC 2.7.11.1

NP_001281259.1

EC 2.7.11.1

NP_001281260.1

EC 2.7.11.1

NP_001281263.1

EC 2.7.11.1

NP_001348925.1

EC 2.7.11.1

XP_006533375.1

EC 2.7.11.1

XP_006533376.1

EC 2.7.11.1

XP_006533379.2

EC 2.7.11.1

XP_006533383.1

EC 2.7.11.1

XP_011247316.1

EC 2.7.11.1

XP_030101858.1

EC 2.7.11.1

XP_030101859.1

EC 2.7.11.1

XP_030101861.1

EC 2.7.11.1

XP_030101862.1

EC 2.7.11.1

XP_036012594.1

EC 2.7.11.1

XP_036012595.1

EC 2.7.11.1

XP_036012596.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112705.2 → NP_001106176.1 serine/threonine-protein kinase tousled-like 2 isoform A

See identical proteins and their annotated locations for NP_001106176.1

Status: VALIDATED

Description

Transcript Variant: This variant (A) encodes the longest isoform (A).

Source sequence(s)

AL645471

Consensus CDS

CCDS48954.1

UniProtKB/TrEMBL

B1ASU9

Related

ENSMUSP00000102554.3, ENSMUST00000106941.9

Conserved Domains (2) summary

COG1196
Location:206 → 503

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:433 → 741

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
NM_001294329.1 → NP_001281258.1 serine/threonine-protein kinase tousled-like 2 isoform C

See identical proteins and their annotated locations for NP_001281258.1

Status: VALIDATED

Description

Transcript Variant: This variant (C) differs in the 5' UTR and lacks two alternate exons in the coding region compared to variant A; the 5'-most initiation codon, as used in variant A, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the alternate AUG to encode an isoform (C) that has a distinct N-terminus, and is shorter, compared to isoform A.

Source sequence(s)

AL645471

Conserved Domains (2) summary

COG1196
Location:102 → 399

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:329 → 637

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
NM_001294330.1 → NP_001281259.1 serine/threonine-protein kinase tousled-like 2 isoform D

Status: VALIDATED

Description

Transcript Variant: This variant (D) lacks two alternate in-frame exons in the 5' coding region and its 3' terminal exon extends past a splice site that is used in variant A. This results in a novel 3' coding region and 3' UTR compared to variant A. The encoded isoform (D) is shorter, and has a distinct C-terminus, compared to isoform A.

Source sequence(s)

AL645471, BC066198

Consensus CDS

CCDS79063.1

UniProtKB/TrEMBL

B7ZC85, Q6NZC4

Related

ENSMUSP00000118520.2, ENSMUST00000145048.8

Conserved Domains (2) summary

smart00220
Location:387 → 592

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:369 → 593

PKc_like; Protein Kinases, catalytic domain
NM_001294331.1 → NP_001281260.1 serine/threonine-protein kinase tousled-like 2 isoform B

See identical proteins and their annotated locations for NP_001281260.1

Status: VALIDATED

Description

Transcript Variant: This variant (B) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant A. The encoded isoform (B) is shorter than isoform A.

Source sequence(s)

AL645471

Consensus CDS

CCDS36356.2

UniProtKB/Swiss-Prot

B1ASU7, B1ASU8, O55047, Q9D5Y5

UniProtKB/TrEMBL

Q6NZC4

Related

ENSMUSP00000102552.3, ENSMUST00000106939.9

Conserved Domains (2) summary

COG1196
Location:174 → 471

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:401 → 709

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
NM_001294334.1 → NP_001281263.1 serine/threonine-protein kinase tousled-like 2 isoform E

Status: VALIDATED

Description

Transcript Variant: This variant (E) contains a 3' terminal exon that extends past a splice site that is used in variant A. This results in a novel 3' coding region and 3' UTR compared to variant A. The encoded isoform (E) is shorter, and has a distinct C-terminus, compared to isoform A.

Source sequence(s)

AK014829, AL645471, BC066198

Consensus CDS

CCDS79062.1

UniProtKB/TrEMBL

Q6NZC4

Related

ENSMUSP00000090198.4, ENSMUST00000092537.10

Conserved Domains (2) summary

smart00220
Location:451 → 656

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:433 → 657

PKc_like; Protein Kinases, catalytic domain
NM_001361996.1 → NP_001348925.1 serine/threonine-protein kinase tousled-like 2 isoform F

Status: VALIDATED

Source sequence(s)

AL645471, AW490750

UniProtKB/TrEMBL

Q6NZC4

Conserved Domains (1) summary

cd14041
Location:369 → 677

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

105066869..105174785

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533312.5 → XP_006533375.1 serine/threonine-protein kinase tousled-like 2 isoform X1

See identical proteins and their annotated locations for XP_006533375.1

UniProtKB/TrEMBL

B1ASU9

Conserved Domains (2) summary

COG1196
Location:206 → 503

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:433 → 741

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_036156701.1 → XP_036012594.1 serine/threonine-protein kinase tousled-like 2 isoform X4

UniProtKB/Swiss-Prot

B1ASU7, B1ASU8, O55047, Q9D5Y5

UniProtKB/TrEMBL

Q6NZC4

Conserved Domains (2) summary

COG1196
Location:174 → 471

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:401 → 709

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_036156702.1 → XP_036012595.1 serine/threonine-protein kinase tousled-like 2 isoform X6

UniProtKB/TrEMBL

Q6NZC4

Conserved Domains (1) summary

cd14041
Location:364 → 672

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_030246002.2 → XP_030101862.1 serine/threonine-protein kinase tousled-like 2 isoform X7

UniProtKB/TrEMBL

Q6NZC4

Conserved Domains (1) summary

cd14041
Location:338 → 646

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_030246001.2 → XP_030101861.1 serine/threonine-protein kinase tousled-like 2 isoform X5

UniProtKB/TrEMBL

Q6NZC4

Conserved Domains (1) summary

cd14041
Location:370 → 678

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_011249014.4 → XP_011247316.1 serine/threonine-protein kinase tousled-like 2 isoform X4

See identical proteins and their annotated locations for XP_011247316.1

UniProtKB/Swiss-Prot

B1ASU7, B1ASU8, O55047, Q9D5Y5

UniProtKB/TrEMBL

Q6NZC4

Related

ENSMUSP00000015107.7, ENSMUST00000015107.13

Conserved Domains (2) summary

COG1196
Location:174 → 471

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:401 → 709

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_030245999.2 → XP_030101859.1 serine/threonine-protein kinase tousled-like 2 isoform X3

UniProtKB/TrEMBL

Q6NZC4

Conserved Domains (2) summary

COG1196
Location:182 → 471

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:401 → 709

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_030245998.2 → XP_030101858.1 serine/threonine-protein kinase tousled-like 2 isoform X1

UniProtKB/TrEMBL

B1ASU9

Conserved Domains (2) summary

COG1196
Location:206 → 503

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:433 → 741

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_006533313.5 → XP_006533376.1 serine/threonine-protein kinase tousled-like 2 isoform X1

See identical proteins and their annotated locations for XP_006533376.1

UniProtKB/TrEMBL

B1ASU9

Conserved Domains (2) summary

COG1196
Location:206 → 503

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:433 → 741

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_036156703.1 → XP_036012596.1 serine/threonine-protein kinase tousled-like 2 isoform X4

UniProtKB/Swiss-Prot

B1ASU7, B1ASU8, O55047, Q9D5Y5

UniProtKB/TrEMBL

Q6NZC4

Conserved Domains (2) summary

COG1196
Location:174 → 471

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:401 → 709

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_006533320.5 → XP_006533383.1 serine/threonine-protein kinase tousled-like 2 isoform X8

See identical proteins and their annotated locations for XP_006533383.1

Conserved Domains (2) summary

COG1196
Location:102 → 399

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14041
Location:329 → 637

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2
XM_006533316.5 → XP_006533379.2 serine/threonine-protein kinase tousled-like 2 isoform X2

Conserved Domains (1) summary

cd14041
Location:396 → 704

STKc_TLK2; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_011903.3: Suppressed sequence

Description

NM_011903.3: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.