Arhgap26 Rho GTPase activating protein 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap26provided by MGI
Official Full Name: Rho GTPase activating protein 26provided by MGI
Primary source: MGI:MGI:1918552
See related: Ensembl:ENSMUSG00000036452 AllianceGenome:MGI:1918552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0621; 1810044B20Rik; 2610010G17Rik; 4933432P15Rik
Summary: Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in mitophagy. Predicted to be located in cytosol and endosome membrane. Predicted to be active in mitochondrion. Is expressed in amygdala; diencephalon lateral wall mantle layer; hypothalamus mantle layer; olfactory epithelium; and telencephalon mantle layer. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 9.3), cortex adult (RPKM 5.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 20.51 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (38734531..39509338)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (38601617..39376285)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
Title: ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility.
GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
Title: GRAF1 integrates PINK1-Parkin signaling and actin dynamics to mediate cardiac mitochondrial homeostasis.
Study shows that brain Pyk2 interacts with the RhoGAP protein Graf1 to alter dendritic spine stability via RhoA GTPase. Amyloid-beta oligomer-induced dendritic spine loss requires the Pyk2/Graf1 pathway.
Title: Pyk2 Signaling through Graf1 and RhoA GTPase Is Required for Amyloid-β Oligomer-Triggered Synapse Loss.
GRAF1 and 2 facilitate myoblast fusion, at least in part, by promoting vesicle-mediated translocation of fusogenic ferlin proteins to the plasma membrane.
Title: GRAF1 promotes ferlin-dependent myoblast fusion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa67b10.seq (e-PCR)
- UniSTS:125260

AI853435 (e-PCR)
- UniSTS:181111

D18Mit193 (e-PCR), detects polymorphism
- UniSTS:128212

BE120196 (e-PCR)
- UniSTS:247262

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 26

Names: rho-type GTPase-activating protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361073.1 → NP_001348002.1 rho GTPase-activating protein 26 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorterC, compared to isoform 1.

Source sequence(s)

AC110730, AC129603, AC132450

Consensus CDS

CCDS89227.1

UniProtKB/TrEMBL

B9EJ96, F6T836

Related

ENSMUSP00000121197.3, ENSMUST00000137497.9

Conserved Domains (4) summary

cd07636
Location:19 → 225

BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase

cd12064
Location:667 → 722

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:364 → 563

RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...

cd01249
Location:267 → 371

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
NM_001374831.1 → NP_001361760.1 rho GTPase-activating protein 26 isoform 3

Status: VALIDATED

Source sequence(s)

AC110730, AC129603, AC132450

Consensus CDS

CCDS89226.1

UniProtKB/TrEMBL

B9EJ96, E9QAQ3

Related

ENSMUSP00000122371.2, ENSMUST00000155576.8

Conserved Domains (4) summary

cd07636
Location:19 → 225

BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase

cd12064
Location:704 → 759

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:364 → 563

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:267 → 371

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
NM_175164.4 → NP_780373.3 rho GTPase-activating protein 26 isoform 1

See identical proteins and their annotated locations for NP_780373.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC007995, AK011368, AK129176, AK152368, BM935209

Consensus CDS

CCDS29205.1

UniProtKB/Swiss-Prot

E9QLL3, Q6ZQ82

UniProtKB/TrEMBL

B9EJ96

Related

ENSMUSP00000095200.3, ENSMUST00000097593.9

Conserved Domains (5) summary

cd07636
Location:19 → 225

BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase

cd12064
Location:759 → 814

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:364 → 563

RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...

cd01249
Location:267 → 371

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

pfam00169
Location:267 → 364

PH; PH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

38734531..39509338

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161285.1 → XP_036017178.1 rho GTPase-activating protein 26 isoform X4

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd12064
Location:676 → 731

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:373 → 572

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:276 → 380

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl12013
Location:61 → 234

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_030250607.2 → XP_030106467.1 rho GTPase-activating protein 26 isoform X2

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd12064
Location:757 → 812

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:362 → 561

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:265 → 369

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl12013
Location:50 → 223

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036161286.1 → XP_036017179.1 rho GTPase-activating protein 26 isoform X5

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd12064
Location:665 → 720

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:362 → 561

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:265 → 369

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl12013
Location:50 → 223

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017317984.2 → XP_017173473.2 rho GTPase-activating protein 26 isoform X2

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd12064
Location:757 → 812

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:362 → 561

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:265 → 369

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl12013
Location:50 → 223

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036161284.1 → XP_036017177.1 rho GTPase-activating protein 26 isoform X1

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd12064
Location:768 → 823

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:373 → 572

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:276 → 380

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl12013
Location:61 → 234

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_006526267.4 → XP_006526330.1 rho GTPase-activating protein 26 isoform X3

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd07636
Location:19 → 225

BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase

cd12064
Location:714 → 769

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:364 → 563

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:267 → 371

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
XM_036161288.1 → XP_036017181.1 rho GTPase-activating protein 26 isoform X8

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd07636
Location:19 → 225

BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:364 → 563

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:267 → 371

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl17036
Location:714 → 740

SH3; Src Homology 3 domain superfamily
XM_030250608.2 → XP_030106468.1 rho GTPase-activating protein 26 isoform X7

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (3) summary

cd07636
Location:19 → 225

BAR_GRAF; The Bin/Amphiphysin/Rvs (BAR) domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:364 → 563

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:267 → 371

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
XM_036161287.1 → XP_036017180.1 rho GTPase-activating protein 26 isoform X6

UniProtKB/TrEMBL

B9EJ96

Conserved Domains (4) summary

cd12064
Location:634 → 689

SH3_GRAF; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase

cd04374
Location:284 → 483

RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...

cd01249
Location:187 → 291

BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain

cl12013
Location:1 → 145

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature