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    Cdh8 cadherin 8 [ Mus musculus (house mouse) ]

    Gene ID: 12564, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdh8provided by MGI
    Official Full Name
    cadherin 8provided by MGI
    Primary source
    MGI:MGI:107434
    See related
    Ensembl:ENSMUSG00000036510 AllianceGenome:MGI:107434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cad8
    Summary
    This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Mice lacking the encoded protein exhibit reduced behavioral responses to cold, but not thermal stimuli. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in CNS E18 (RPKM 7.5), whole brain E14.5 (RPKM 4.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdh8 in Genome Data Viewer
    Location:
    8 D1; 8 49.4 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (99751103..100144298, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (99024471..99417666, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22444 Neighboring gene STARR-seq mESC enhancer starr_22445 Neighboring gene predicted gene, 23494 Neighboring gene STARR-seq mESC enhancer starr_22446 Neighboring gene STARR-seq mESC enhancer starr_22447 Neighboring gene STARR-seq mESC enhancer starr_22448 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene STARR-seq mESC enhancer starr_22449 Neighboring gene predicted gene 15679 Neighboring gene predicted gene, 24693 Neighboring gene protein phosphatase 4, regulatory subunit 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22450 Neighboring gene STARR-seq mESC enhancer starr_22451 Neighboring gene RIKEN cDNA A330008L17 gene Neighboring gene STARR-seq mESC enhancer starr_22453 Neighboring gene STARR-seq mESC enhancer starr_22454 Neighboring gene STARR-seq mESC enhancer starr_22455 Neighboring gene STARR-seq mESC enhancer starr_22456 Neighboring gene STARR-seq mESC enhancer starr_22457 Neighboring gene STARR-seq mESC enhancer starr_22458 Neighboring gene STARR-seq mESC enhancer starr_22459 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22461 Neighboring gene inosine monophosphate dehydrogenase 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits. Friedman LG, et al. J Comp Neurol, 2015 Jan 1. PMID 25158904, Free PMC Article
    2. Expression of cadherin-8 mRNA in the developing mouse central nervous system. Korematsu K, et al. J Comp Neurol, 1997 Oct 20. PMID 9336230
    3. Cortical area size dictates performance at modality-specific behaviors. Leingärtner A, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360492, Free PMC Article
    4. Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins. Miloushev VZ, et al. Structure, 2008 Aug 6. PMID 18682221, Free PMC Article
    5. Development and cadherin-mediated control of prefrontal corticostriatal projections in mice. Mesías RE, et al. iScience, 2023 Oct 20. PMID 37854688, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The autism-associated protein CHD8 is required for cerebellar development and motor function.
      Title: The autism-associated protein CHD8 is required for cerebellar development and motor function.
    2. Cdh8 has role in neurogenesis in the ventral telencephalon during development.
      Title: Cadherin 8 regulates proliferation of cortical interneuron progenitors.
    3. Results indicate that Cdh8 delineates developing corticostriatal circuits where it is a strong candidate for regulating the generation of normal cortical projections, neuronal morphology, and corticostriatal synapses
      Title: Cadherin-8 expression, synaptic localization, and molecular control of neuronal form in prefrontal corticostriatal circuits.
    4. Study shows that bipolar cells BC2s and BC5s deliver visual input to neurons that compute direction of motion and demonstrate that Cdh8 and Cdh9 are required for assembly of the circuit.
      Title: Type II cadherins guide assembly of a direction-selective retinal circuit.
    5. Results describe individual monomer and dimer states and the monomer-dimer equilibrium of the mouse Type II cadherin-8 EC1 domain.
      Title: Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins.
    6. These results demonstrate that cad8 is essential for establishing the physiological coupling between cold-sensitive sensory neurons and their target DH neurons.
      Title: Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in synaptic cleft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin-8

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039154.2 → NP_001034243.1  cadherin-8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001034243.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the 3' coding region that leads to a frameshift compared to variant 2. The resulting protein (isoform 1) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (1) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AC103397, BC057581, BU058167
      Consensus CDS
      CCDS22569.1
      UniProtKB/TrEMBL
      Q8C375, Q8C449
      Related
      ENSMUSP00000090935.5, ENSMUST00000093249.11
      Conserved Domains (3) summary
      cd11304
      Location:281 → 387
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:653 → 708
      Cadherin_C; Cadherin cytoplasmic region

    2. NM_001285913.1 → NP_001272842.1  cadherin-8 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon compared to variant 2. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (3) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AK044046, AK139334, BC057581, BU058167
      Consensus CDS
      CCDS72155.1
      UniProtKB/TrEMBL
      E9Q451, Q8BRK4
      Related
      ENSMUSP00000123619.2, ENSMUST00000155527.8
      Conserved Domains (3) summary
      cd11304
      Location:281 → 387
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:653 → 711
      Cadherin_C; Cadherin cytoplasmic region

    3. NM_001285914.1 → NP_001272843.1  cadherin-8 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region and includes an alternate 3' terminal exon compared to variant 2. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 2. This isoform (4) may undergo proteolytic processing similar to isoform 2.
      Source sequence(s)
      AK044046, AK139334, BC057581, BU058167
      Consensus CDS
      CCDS72156.1
      UniProtKB/TrEMBL
      E9PYB2, Q3UTL9
      Related
      ENSMUSP00000114507.2, ENSMUST00000142129.8
      Conserved Domains (3) summary
      cd11304
      Location:281 → 387
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:653 → 701
      Cadherin_C; Cadherin cytoplasmic region

    4. NM_007667.3 → NP_031693.2  cadherin-8 isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_031693.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest protein (isoform 2).
      Source sequence(s)
      AC103397, BC057581, BU058167
      Consensus CDS
      CCDS40448.1
      UniProtKB/Swiss-Prot
      G3UVU4, P97291
      UniProtKB/TrEMBL
      Q3UTL9
      Related
      ENSMUSP00000117326.2, ENSMUST00000128860.8
      Conserved Domains (3) summary
      cd11304
      Location:281 → 387
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:645 → 790
      Cadherin_C; Cadherin cytoplasmic region

    RNA

    1. NR_133570.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 3' terminus, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC102643, AC103397, BC060200, BU058167
      Related
      ENSMUST00000145601.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      99751103..100144298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243274.1 → XP_030099134.1  cadherin-8 isoform X1

      UniProtKB/Swiss-Prot
      G3UVU4, P97291
      UniProtKB/TrEMBL
      Q3UTL9
      Conserved Domains (3) summary
      cd11304
      Location:281 → 387
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:645 → 790
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_017312551.3 → XP_017168040.1  cadherin-8 isoform X3

      Conserved Domains (2) summary
      smart00112
      Location:17 → 55
      CA; Cadherin repeats
      pfam01049
      Location:98 → 243
      Cadherin_C; Cadherin cytoplasmic region

    3. XM_006530631.3 → XP_006530694.1  cadherin-8 isoform X1

      See identical proteins and their annotated locations for XP_006530694.1

      UniProtKB/Swiss-Prot
      G3UVU4, P97291
      UniProtKB/TrEMBL
      Q3UTL9
      Conserved Domains (3) summary
      cd11304
      Location:281 → 387
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:645 → 790
      Cadherin_C; Cadherin cytoplasmic region

    4. XM_006530634.5 → XP_006530697.1  cadherin-8 isoform X2

      UniProtKB/TrEMBL
      Q8BRK4
      Conserved Domains (3) summary
      cd11304
      Location:281 → 387
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:87 → 165
      CA; Cadherin repeats
      pfam01049
      Location:645 → 700
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97291.2 GenPept UniProtKB/Swiss-Prot:P97291

    Gene LinkOut

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