U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Itpkc inositol 1,4,5-trisphosphate 3-kinase C [ Mus musculus (house mouse) ]

    Gene ID: 233011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itpkcprovided by MGI
    Official Full Name
    inositol 1,4,5-trisphosphate 3-kinase Cprovided by MGI
    Primary source
    MGI:MGI:2442554
    See related
    Ensembl:ENSMUSG00000003752 AllianceGenome:MGI:2442554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IP3K C; 9130023N17Rik
    Summary
    Enables inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in cellular response to calcium ion; inositol phosphate biosynthetic process; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in nuclear speck. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including blastocyst and early embryo. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human ITPKC (inositol-trisphosphate 3-kinase C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 13.8), large intestine adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itpkc in Genome Data Viewer
    Location:
    7 A3; 7 15.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26906595..26928042, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27207170..27228617, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3707 Neighboring gene small nuclear ribonucleoprotein polypeptide A Neighboring gene actin maturation protease Neighboring gene microRNA 1191 Neighboring gene STARR-positive B cell enhancer ABC_E2229 Neighboring gene coenzyme Q8B Neighboring gene STARR-positive B cell enhancer ABC_E4906 Neighboring gene numb-like Neighboring gene ribosomal protein L14 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol-1,4,5-trisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    inositol-trisphosphate 3-kinase C
    Names
    IP3 3-kinase C
    insP 3-kinase C
    NP_853624.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181593.3NP_853624.1  inositol-trisphosphate 3-kinase C

      See identical proteins and their annotated locations for NP_853624.1

      Status: VALIDATED

      Source sequence(s)
      BC053450, BY275976
      Consensus CDS
      CCDS21015.1
      UniProtKB/Swiss-Prot
      Q3U384, Q7TS72
      Related
      ENSMUSP00000003850.8, ENSMUST00000003850.8
      Conserved Domains (1) summary
      pfam03770
      Location:462673
      IPK; Inositol polyphosphate kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26906595..26928042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)